Evidence map›Paper›PMID 33761957›Full record

ReviewJournal of biomedical science2021

Regulation of autophagy by microRNAs in human breast cancer.

Zhi Xiong Chong, Swee Keong Yeap, Wan Yong Ho

Open access · diamondAbstract readReview
In one paragraph

Review in Journal of biomedical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Autophagy andFrontiers in cellular and infection microbiology · 2026
    Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Zhi Xiong ChongFaculty of Science and Engineering, University of Nottingham Malaysia, 43500, Semenyih, Selangor, Malaysia.
Swee Keong YeapChina-ASEAN College of Marine Sciences, Xiamen University Malaysia, 43900, Sepang, Selangor, Malaysia.
Wan Yong HoFaculty of Science and Engineering, University of Nottingham Malaysia, 43500, Semenyih, Selangor, Malaysia. WanYong.Ho@nottingham.edu.my.ORCID http://orcid.org/0000-0001-5768-0738
University of Nottingham Malaysia Campus · MYXiamen University Malaysia · MY

Funding

Ministry of Higher Education, Malaysia FRGS/1/2014/SG05/UNIM/02/1Ministry of Higher Education, Malaysia FRGS/1/2018/STG05/UNIM/02/1
6 · The paper itself

Abstract

Breast cancer is the most common solid cancer that affects female population globally. MicroRNAs (miRNAs) are short non-coding RNAs that can regulate post-transcriptional modification of multiple downstream genes. Autophagy is a conserved cellular catabolic activity that aims to provide nutrients and degrade un-usable macromolecules in mammalian cells. A number of in vitro, in vivo and clinical studies have reported that some miRNAs could modulate autophagy activity in human breast cancer cells, and these would influence human breast cancer progression and treatment response. Therefore, this review was aimed to discuss the roles of autophagy-regulating miRNAs in influencing breast cancer development and treatment response. The review would first introduce autophagy types and process, followed by the discussion of the roles of different miRNAs in modulating autophagy in human breast cancer, and to explore how would this miRNA-autophagy regulatory process affect the disease progression or treatment response. Lastly, the potential applications and challenges of utilizing autophagy-regulating miRNAs as breast cancer biomarkers and novel therapeutic agents would be discussed.

Indexed as

AutophagyGene Expression Regulation, NeoplasticBiomarkers, TumorBreast NeoplasmsFemaleHumansMicroRNAsSignal TransductionBiomarkers, TumorMicroRNAsAutophagyBiomarkersBreast cancermiRNAsTherapeutic agents

Identifiers

PMID33761957
PMCPMC7992789
OpenAlexW3139002161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.