Evidence map›Paper›PMID 33761917›Full record

ArticleBMC pediatrics2021

Growth and neurodevelopment in low birth weight versus normal birth weight infants from birth to 24 months, born in an obstetric emergency hospital in Haiti, a prospective cohort study.

Marjorie Hilaire, Xanthi D Andrianou, Annick Lenglet, Cono Ariti, Kessiane Charles, Sonja Buitenhuis, Daan Van Brusselen, Harriet Roggeveen, Elizabeth Ledger, Rodnie Selva Denat and 1 more

Abstract read
In one paragraph

Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Head Growth Trajectories During the First Year of Life and Risk of Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marjorie Hilaire *Médecins Sans Frontières, Port au Prince, Haiti.
Xanthi D Andrianou *Médecins Sans Frontières, Plantage Middenlaan 14, 1018DD, Amsterdam, The Netherlands.
Annick Lenglet *Médecins Sans Frontières, Plantage Middenlaan 14, 1018DD, Amsterdam, The Netherlands. annick.lenglet@amsterdam.msf.org.ORCID 0000-0003-2013-8405
Cono AritiCentre for Trials Research, Cardiff University Medical School, Cardiff, UK.
Kessiane CharlesMédecins Sans Frontières, Port au Prince, Haiti.
Sonja BuitenhuisMédecins Sans Frontières, Port au Prince, Haiti.
Daan Van BrusselenMédecins Sans Frontières, Plantage Middenlaan 14, 1018DD, Amsterdam, The Netherlands.
Harriet RoggeveenMédecins Sans Frontières, Plantage Middenlaan 14, 1018DD, Amsterdam, The Netherlands.
Elizabeth LedgerMédecins Sans Frontières, Port au Prince, Haiti.
Rodnie Selva DenatMédecins Sans Frontières, Port au Prince, Haiti.
Lindsay BrysonMédecins Sans Frontières, Port au Prince, Haiti.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow birthweight (LBW) infants are at higher risk of mortality and morbidity (growth, chronic disease and neurological problems) during their life. Due to the high incidence of (pre-) eclampsia in Haiti, LBW infants are common. We assessed the anthropometric growth (weight and length) and neurodevelopmental delay in LBW and normal birthweight (NBW) infants born at an obstetric emergency hospital in Port au Prince, Haiti, between 2014 and 2017.

methodsInfants were followed at discharge and 3, 6, 12, 15, 18, 21 and 24 months of corrected gestational age. At each visit they underwent a physical checkup (weight, length, physical abnormalities, identification of morbidities). At 6, 12, 18 and 24 months they underwent a neurodevelopmental assessment using the Bayley Scale III (motor, cognitive and communication skills). We modelled the trajectories between birth and 24 months of age of NBW compared to LBW infants for weight, length, and raw scores for Bayley III assessments using mixed linear models.

resultsIn total 500 LBW and 210 NBW infants were recruited of which 333 (46.7%) were followed up for 24 months (127 NBW; 60.5% and 206 LBW; 41.2%) and 150 died (LBW = 137 and NBW = 13). LBW and NBW babies gained a mean 15.8 g and 11.4 g per kg of weight from discharge per day respectively. The speed of weight gain decreased rapidly after 3 months in both groups. Both groups grow rapidly up to 6 months of age. LBW grew more than the NBW group during this period (22.8 cm vs. 21.1 cm). Both groups had WHZ scores <- 2 up to 15 months. At 24 months NBW babies scored significantly higher on the Bayley scales for gross motor, cognitive and receptive and expressive communication skills. There was no difference between the groups for fine motor skills.

conclusionLBW babies that survive neonatal care in urban Haiti and live up to 24 months of age, perform similar to their NBW for weight, length and fine motor skills. LBW babies are delayed in gross motor, cognitive and communication skills development. Further research on the clinical significance of these findings and long term implications of this neurodevelopmental delay is needed.

Indexed as

HospitalsInfant, Low Birth WeightBirth WeightFemaleHaitiHumansInfantInfant, NewbornPregnancyProspective Studies

Identifiers

PMID33761917
PMCPMC7988959

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.