Evidence map›Paper›PMID 33761894›Full record

Trial reportBMC anesthesiology2021

Bilateral posterior Quadratus Lumborum block for pain relief after cesarean delivery: a randomized controlled trial.

Pawinee Pangthipampai, Sukanya Dejarkom, Suppachai Poolsuppasit, Choopong Luansritisakul, Suwida Tangchittam

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03199170 nacompletednot on this map

Effect of Bilateral Quadratus Lumborum Block for Pain Relief in Patients With Cesarean Section

TypeinterventionalSponsorMahidol UniversityRan2017 to 2019Enrolled90ConditionsCaesarean Section, Spinal Anesthesia, Quadratus Lumborum Block, AnalgesiaArmsIntrathecal morphine, Bilateral Quadratus Lumborum Block, Intrathecal morphine with bilateral Quadratus Lumborum Block
NCT07490795 completednot on this mapstarted 2025, after this paper: background citation

The Effects of Intrathecal Morphine and Ultrasound-Guided Bilateral Transversalis Fascia Plane Block on Postoperative Acute Pain and Patient Satisfaction in Patients Undergoing Elective Cesarean Section

Typeobservational_patient_registrySponsorVezirköprü State HospitalRan2025 to 2026Enrolled117ConditionsCaesarean Section, Postoperative Analgesia
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pawinee PangthipampaiDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand. pawinee141@gmail.com.ORCID 0000-0002-2574-7667
Sukanya DejarkomDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.
Suppachai PoolsuppasitDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.
Choopong LuansritisakulDepartment of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.
Suwida TangchittamDepartment of Anesthesiology, Police General Hospital, Bangkok, Thailand.
Siriraj Hospital · THPolice General Hospital · TH

Funding

Faculty of Medicine Siriraj Hospital, Mahidol University R016032030
6 · The paper itself

Abstract

backgroundAchieving optimal analgesia with few side effects is the goal of pain management after cesarean delivery. Intrathecal (IT) morphine is the current standard but ultrasound-guided quadratus lumborum block (QLB) may offer superior pain control with fewer side effects. This study compared the pain-free period after cesarean delivery among parturients who received spinal block with IT morphine, with IT morphine and bilateral QLB, or only bilateral QLB.

methodsParturients having elective cesarean delivery under spinal block were randomized and allocated into IT morphine 0.2 mg with sham QLB (Group IT), IT morphine 0.2 mg and bilateral QLB with 0.25% bupivacaine 25 ml in each side (Group IT+QLB), or bilateral QLB with 0.25% bupivacaine 25 ml in each side (Group QLB). A PCA pump was connected after completion of the QLB or sham block. The first time to PCA morphine requirement was recorded and compared.

resultsEighty parturients were included. Analysis of Group QLB was terminated early because at the second interim analysis, median pain-free period was significantly shorter in Group QLB [hours (95%CI): 2.50 (1.04-3.96) in Group IT vs. 7.75 (5.67-9.83) in IT+QLB vs. 1.75 (0.75-2.75) in QLB (p < 0.001)]. The median (min, max) amount of morphine required during 24 h was 5.5 (0-25) in Group IT vs. 5.0 (0-36) in IT+QLB vs. 17.5 (1-40) mg in Group QLB (p < 0.001). In the final analysis the median pain-free period was 2.50 (1.23-3.77) hours (95%CI) in Group IT (n = 27) vs. 8.02 (5.96-10.07) in IT+QLB (n = 28). (p = 0.027).

conclusionUS-QLB used in conjunction with IT morphine yielded a statistically significant longer median pain-free period compared with standard IT morphine alone. However, QLB alone provided inferior pain control compared with standard IT morphine. When combined with IT morphine, QLB could provide additional analgesic benefit as a part of multimodal analgesic regimen, especially during the early postoperative period.

trial registrationClinicalTrials.gov no. NCT03199170 Date registered on June 22, 2017. Prospectively registered.

Indexed as

Cesarean SectionNerve BlockAdultAnalgesia, Patient-ControlledAnalgesics, OpioidAnesthesia, SpinalAnesthetics, LocalBack MusclesBupivacaineDrug UtilizationFemaleHumansMorphinePostoperative PainPregnancyAnalgesics, OpioidAnesthetics, LocalBupivacaineMorphineBilateral posterior quadratus lumborum blockCesarean deliveryPain reliefUltrasound-guided QLB

Identifiers

PMID33761894
PMCPMC7992995
OpenAlexW3123482060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.