Evidence map›Paper›PMID 33761765›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice.

Latha Muniappan, Michihiro Okuyama, Aida Javidan, Devi Thiagarajan, Weihua Jiang, Jessica J Moorleghen, Lihua Yang, Anju Balakrishnan, Deborah A Howatt, Haruhito A Uchida and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Calpain-2-Mediated Endothelial Focal Adhesion Disruption in Thoracic Aortic Dissection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Observational
  7. Article
  8. Article
  9. Mechanosignals in abdominal aortic aneurysms.Frontiers in cardiovascular medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Latha MuniappanSaha Cardiovascular Research Center (L.M., M.O., A.J., D.T., W.J., J.J.M., L.Y., A.B., D.A.H., V.S.), University of Kentucky, Lexington.
Michihiro OkuyamaSaha Cardiovascular Research Center (L.M., M.O., A.J., D.T., W.J., J.J.M., L.Y., A.B., D.A.H., V.S.), University of Kentucky, Lexington.
Aida JavidanSaha Cardiovascular Research Center (L.M., M.O., A.J., D.T., W.J., J.J.M., L.Y., A.B., D.A.H., V.S.), University of Kentucky, Lexington.
Devi ThiagarajanSaha Cardiovascular Research Center (L.M., M.O., A.J., D.T., W.J., J.J.M., L.Y., A.B., D.A.H., V.S.), University of Kentucky, Lexington.
Weihua JiangSaha Cardiovascular Research Center (L.M., M.O., A.J., D.T., W.J., J.J.M., L.Y., A.B., D.A.H., V.S.), University of Kentucky, Lexington.
Jessica J MoorleghenSaha Cardiovascular Research Center (L.M., M.O., A.J., D.T., W.J., J.J.M., L.Y., A.B., D.A.H., V.S.), University of Kentucky, Lexington.
Lihua YangSaha Cardiovascular Research Center (L.M., M.O., A.J., D.T., W.J., J.J.M., L.Y., A.B., D.A.H., V.S.), University of Kentucky, Lexington.
Anju BalakrishnanSaha Cardiovascular Research Center (L.M., M.O., A.J., D.T., W.J., J.J.M., L.Y., A.B., D.A.H., V.S.), University of Kentucky, Lexington.
Deborah A HowattSaha Cardiovascular Research Center (L.M., M.O., A.J., D.T., W.J., J.J.M., L.Y., A.B., D.A.H., V.S.), University of Kentucky, Lexington.
Haruhito A UchidaDepartment of Chronic Kidney Disease and Cardiovascular Disease, Okayama University School of Medicine, Dentistry and Pharmaceuticals Sciences, Japan (H.A.U.).
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama, Japan (T.C.S.).
Venkateswaran SubramanianSaha Cardiovascular Research Center (L.M., M.O., A.J., D.T., W.J., J.J.M., L.Y., A.B., D.A.H., V.S.), University of Kentucky, Lexington.
University of Kentucky · USOkayama University · JPRIKEN Center for Brain Science · JP

Funding

The role of IKKß in linking obesity to adipose tissue inflammation and adipogeneP20GM103527 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2012 to 2017
$13.7M
Pilot Projects ProgramP30GM127211 · NIGMS · UNIVERSITY OF KENTUCKY · PI CASSIS, LISA A · 2018 to 2022
$5.7M
Calpains and Abdominal Aortic AneurysmsR01HL130086 · NHLBI · UNIVERSITY OF KENTUCKY · PI SUBRAMANIAN, VENKATESWARAN · 2017 to 2020
$1.9M
NHLBI NIH HHS R01 HL130086NIGMS NIH HHS P20 GM103527NIGMS NIH HHS P30 GM127211
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Vascular RemodelingAgedAged, 80 and overAngiotensin IIAnimalsAorta, AbdominalAortic Aneurysm, AbdominalAortic RuptureCalpainCells, CulturedCytoskeletonDilatation, PathologicDisease Models, AnimalExtracellular MatrixFemaleHumansAngiotensin IICalpainCAPN2 protein, humanCapn2 protein, mouseCapn2 protein, ratReceptors, LDLangiotensin IIcalpaincytoskeletal proteinfilamin Atamoxifen

Identifiers

PMID33761765
PMCPMC8062307
OpenAlexW3137725305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.