Evidence map›Paper›PMID 33761760›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2021

Deficiency of MMP1a (Matrix Metalloprotease 1a) Collagenase Suppresses Development of Atherosclerosis in Mice: Translational Implications for Human Coronary Artery Disease.

Elizabeth K Fletcher, Yanling Wang, Laura K Flynn, Susan E Turner, Jeffrey J Rade, Carey D Kimmelstiel, Paul A Gurbel, Kevin P Bliden, Lidija Covic, Athan Kuliopulos

Open access · bronzeAbstract read
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Elizabeth K FletcherCenter for Hemostasis and Thrombosis Research, Division of Hematology-Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (E.K.F., Y.W., L.K.F, S.E.T., L.C., A.K.).
Yanling WangCenter for Hemostasis and Thrombosis Research, Division of Hematology-Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (E.K.F., Y.W., L.K.F, S.E.T., L.C., A.K.).
Laura K FlynnCenter for Hemostasis and Thrombosis Research, Division of Hematology-Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (E.K.F., Y.W., L.K.F, S.E.T., L.C., A.K.).
Susan E TurnerCenter for Hemostasis and Thrombosis Research, Division of Hematology-Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (E.K.F., Y.W., L.K.F, S.E.T., L.C., A.K.).
Jeffrey J RadeInterventional Cardiology, Division of Cardiology, University of Massachusetts Memorial Medical Center, University of Massachusetts Medical School, Worcester (J.J.R.).
Carey D KimmelstielAdult Interventional Cardiology, Division of Cardiology, Tufts Medical Center, Boston, MA (C.D.K.).
Paul A GurbelInova Center for Thrombosis Research and Translational Medicine, Inova Fairfax Hospital, Falls Church, VA (P.A.G., K.P.B.).
Kevin P BlidenInova Center for Thrombosis Research and Translational Medicine, Inova Fairfax Hospital, Falls Church, VA (P.A.G., K.P.B.).
Lidija CovicCenter for Hemostasis and Thrombosis Research, Division of Hematology-Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (E.K.F., Y.W., L.K.F, S.E.T., L.C., A.K.).
Athan KuliopulosCenter for Hemostasis and Thrombosis Research, Division of Hematology-Oncology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA (E.K.F., Y.W., L.K.F, S.E.T., L.C., A.K.).
Tufts University · USInova Fairfax Hospital · USMemorial Medical Center · USTufts Medical Center · US

Funding

TRIP-PCI: PAR1 Pepducin-Based Interventions in Arterial ThrombosisP50HL110789 · NHLBI · TUFTS MEDICAL CENTER · PI KULIOPULOS, ATHAN · 2012 to 2016
$10.0M
Matrix Metalloprotease-PAR1 Regulation of AtherosclerosisR01HL136485 · NHLBI · TUFTS MEDICAL CENTER · PI KULIOPULOS, ATHAN · 2018 to 2021
$2.8M
NHLBI NIH HHS P50 HL110789NHLBI NIH HHS R01 HL136485
6 · The paper itself

Abstract

[Figure: see text].

Indexed as

Acute Coronary SyndromeAnimalsAortaAtherosclerosisCardiac CatheterizationCell-Penetrating PeptidesCells, CulturedCoronary Artery DiseaseDisease Models, AnimalFemaleFibrillar CollagensFibrosisHumansLipopeptidesMaleMatrix Metalloproteinase 1Cell-Penetrating PeptidesFibrillar CollagensLipopeptidesMatrix Metalloproteinase 1Mmp1a protein, mouseMMP1 protein, humanPZ-128 peptideatherosclerosiscollagenfibrillar collagensmonocytesnecrosis

Identifiers

PMID33761760
PMCPMC8062306
OpenAlexW3136251712

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.