Evidence map›Paper›PMID 33761755›Full record

ArticleJournal of the American Heart Association2021

Estimated Impact of Achieving Optimal Cardiovascular Health Among US Adults on Cardiovascular Disease Events.

Joshua D Bundy, Zhengbao Zhu, Hongyan Ning, Victor W Zhong, Amanda E Paluch, John T Wilkins, Donald M Lloyd-Jones, Paul K Whelton, Jiang He, Norrina B Allen

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Dietary patterns to promote cardiometabolic health.Nature reviews. Cardiology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Joshua D BundyDepartment of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA.
Zhengbao ZhuDepartment of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA.
Hongyan NingDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.
Victor W ZhongDepartment of Epidemiology and Biostatistics School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China.
Amanda E PaluchDepartment of Kinesiology University of Massachusetts Amherst Amherst MA.
John T WilkinsDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.
Donald M Lloyd-JonesDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.
Paul K WheltonDepartment of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA.
Jiang HeDepartment of Epidemiology Tulane University School of Public Health and Tropical Medicine New Orleans LA.
Norrina B AllenDepartment of Preventive Medicine Northwestern University Feinberg School of Medicine Chicago IL.

Funding

Tulane COBRE in Cardiometabolic Diseases Clinical Research CoreP20GM109036 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI Yoriko Heianza · 2016 to 2026
$25.3M
Tulane Building Interdisciplinary Research Careers in Women's Health (BIRCWH)K12HD043451 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI KROUSEL-WOOD, MARIE · 2002 to 2023
$9.9M
Mechanism and Modulation of Sex Differences in Myocardial Steatosis Induced Left Ventricular DysfunctionR01HL136601 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI NELSON, MICHAEL DOUGLAS · 2018 to 2022
$3.3M
Epigenetic Determinants of Lipoproteins Across the Early Adult Life CourseR01HL146844 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WILKINS, JOHN THOMAS · 2020 to 2023
$2.2M
Building Interdisciplinary Research Careers in Women's HealthK12AR084224 · NIAMS · TULANE UNIVERSITY OF LOUISIANA · PI Marie Krousel-Wood · 2024 to 2026
$1.6M
Epidemiologic Study of Ethnicity and Lifetime Risks for Cardiovascular DiseaseR21HL085375 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2006 to 2007
$297k
NHLBI NIH HHS R01 HL136601NHLBI NIH HHS R01 HL146844NHLBI NIH HHS R21 HL085375NIAMS NIH HHS K12 AR084224NICHD NIH HHS K12 HD043451NIGMS NIH HHS P20 GM109036
6 · The paper itself

Abstract

Background Better cardiovascular health (CVH) scores are associated with lower risk of cardiovascular disease (CVD). However, estimates of the potential population-level impact of improving CVH on US CVD event rates are not currently available. Methods and Results Using data from the National Health and Nutrition Examination Survey 2011 to 2016 (n=11 696), we estimated the proportions of US adults in CVH groups. Levels of 7 American Heart Association CVH metrics were scored as ideal (2 points), intermediate (1 point), or poor (0 points), and summed to define overall CVH (low, 0-8 points; moderate, 9-11 points; or high, 12-14 points). Using individual-level data from 7 US community-based cohort studies (n=30 447), we estimated annual incidence rates of major CVD events by levels of CVH. Using the combined data sources, we estimated population attributable fractions of CVD and the number of CVD events that could be prevented annually if all US adults achieved high CVH. High CVH was identified in 7.3% (95% CI, 6.3%-8.3%) of US adults. We estimated that 70.0% (95% CI, 56.5%-79.9%) of CVD events were attributable to low and moderate CVH. If all US adults attained high CVH, we estimated that 2.0 (95% CI, 1.6-2.3) million CVD events could be prevented annually. If all US adults with low CVH attained moderate CVH, we estimated that 1.2 (95% CI, 1.0-1.4) million CVD events could be prevented annually. Conclusions The potential benefits of achieving high CVH in all US adults are considerable, and even a partial improvement in CVH scores would be highly beneficial.

Indexed as

Health StatusAdultCardiovascular DiseasesFemaleHumansIncidenceMaleNutrition SurveysRisk AssessmentRisk FactorsUnited StatesYoung Adultcardiovascular diseaseepidemiologyhealth status disparitiespreventionrisk factors

Identifiers

PMID33761755
PMCPMC8174373

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.