Evidence map›Paper›PMID 33761597›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2021

Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice.

Chethan Sampath, Derek Wilus, Mohammad Tabatabai, Michael L Freeman, Pandu R Gangula

Open access · goldAbstract read
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Common Pathophysiological Mechanisms and Treatment of Diabetic Gastroparesis.Journal of neurogastroenterology and motility · 2024
    Review
  9. Cinnamaldehyde Protects againstInternational journal of molecular sciences · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chethan SampathDepartment of ODS & Research, School of Dentistry, Meharry Medical College, Nashville, TN, USA.
Derek WilusBiostatistics, School of Graduate Studies & Research, Meharry Medical College, Nashville, TN, USA.
Mohammad TabatabaiBiostatistics, School of Graduate Studies & Research, Meharry Medical College, Nashville, TN, USA.
Michael L FreemanDepartment of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
Pandu R GangulaDepartment of ODS & Research, School of Dentistry, Meharry Medical College, Nashville, TN, USA. Electronic address: pgangula@mmc.edu.
Meharry Medical College · USVanderbilt University Medical Center · US

Funding

Endowment for Health Disparities ResearchS21MD000104 · NIMHD · MEHARRY MEDICAL COLLEGE · PI HILDRETH, JAMES E · 2001 to 2016
$73.1M
The RCMI Program in Health Disparities Research at Meharry Medical College - SupplementU54MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI Samuel Evans Adunyah · 2017 to 2026
$48.2M
Meharry RCMI Program in Women's Health ResearchG12MD007586 · NIMHD · MEHARRY MEDICAL COLLEGE · PI HILDRETH, JAMES E · 2012 to 2016
$7.8M
ROLE OF NRF2 IN NITRERGIC MEDIAITED STOMACH MOTILITYSC1GM121282 · NIGMS · MEHARRY MEDICAL COLLEGE · PI GANGULA, PANDU R · 2017 to 2020
$1.4M
NIGMS NIH HHS SC1 GM121282NIMHD NIH HHS G12 MD007586NIMHD NIH HHS S21 MD000104NIMHD NIH HHS U54 MD007586
6 · The paper itself

Abstract

Diabetic gastroparesis (DG) exhibits delayed gastric emptying (GE) due to impaired gastric non-adrenergic, non-cholinergic (NANC) relaxation. These defects are due to loss or reduction of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) that causes reduced expression and/or dimerization of neuronal nitric oxide synthase alpha (nNOSα) gene expression and function. We investigated the effect of potent Nrf2 activators (cinnamaldehyde [CNM] & curcumin [CUR]) on GE in obesity-induced diabetic female mice. We fed adult female homozygous Nfe2l2

Indexed as

Diet, High-FatAcroleinAnimalsAntioxidantsCurcuminDiabetes Mellitus, ExperimentalFemaleGastric EmptyingGene ExpressionMiceMice, KnockoutNF-E2-Related Factor 2Nitric OxideNitric Oxide Synthase Type IOxidative StressPyloric AntrumAcroleinAntioxidantscinnamaldehydeCurcuminNfe2l2 protein, mouseNF-E2-Related Factor 2Nitric OxideNitric Oxide Synthase Type INos1 protein, mouseCinnamaldehydeCurcuminGastric emptyingInflammationNitrergic relaxationnNOSNrf2

Identifiers

PMID33761597
PMCPMC7994545
OpenAlexW3133364810

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.