Evidence map›Paper›PMID 33761394›Full record

ArticleJournal of colloid and interface science2021

Evaluation of kinetics and thermodynamics of interaction between immobilized SARS-CoV-2 nucleoprotein and specific antibodies by total internal reflection ellipsometry.

Ieva Plikusiene, Vincentas Maciulis, Almira Ramanaviciene, Zigmas Balevicius, Ernesta Buzavaite-Verteliene, Evaldas Ciplys, Rimantas Slibinskas, Martynas Simanavicius, Aurelija Zvirbliene, Arunas Ramanavicius

Open access · greenAbstract read
In one paragraph

Article in Journal of colloid and interface science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 54 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ieva PlikusieneNanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, 03225 Vilnius, Lithuania; State Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania.
Vincentas MaciulisNanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, 03225 Vilnius, Lithuania; State Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania.
Almira RamanavicieneNanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, 03225 Vilnius, Lithuania.
Zigmas BaleviciusState Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania.
Ernesta Buzavaite-VertelieneState Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania.
Evaldas CiplysInstitute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio ave. 7, LT-10257 Vilnius, Lithuania.
Rimantas SlibinskasInstitute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio ave. 7, LT-10257 Vilnius, Lithuania.
Martynas SimanaviciusInstitute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio ave. 7, LT-10257 Vilnius, Lithuania.
Aurelija ZvirblieneInstitute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio ave. 7, LT-10257 Vilnius, Lithuania.
Arunas RamanaviciusNanoTechnas - Center of Nanotechnology and Materials Science, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko str. 24, 03225 Vilnius, Lithuania; State Research Institute Center for Physical and Technological Sciences, Sauletekio ave. 3, Vilnius, Lithuania.
Center for Physical Sciences and Technology · LTVilnius University · LT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During the pandemic, different methods for SARS-CoV-2 detection and COVID-19 diagnostics were developed, including antibody and antigen tests. For a better understanding of the interaction mechanism between SARS-CoV-2 virus proteins and specific antibodies, total internal reflection ellipsometry based evaluation of the interaction between SARS-CoV-2 nucleoprotein (SCoV2-rN) and anti-SCoV2-rN antibodies was performed. Results show that the appropriate mathematical model, which takes into account the formation of an intermediate complex, can be applied for the evaluation of SCoV2-rN/anti-SCoV2-rN complex formation kinetics. The calculated steric factor indicated that SCoV2-rN/anti-SCoV2-rN complex formation has very strict steric requirements. Estimated Gibbs free energy (ΔG

Indexed as

SARS-CoV-2Antibodies, ViralKineticsNucleoproteinsThermodynamicsAntibodies, ViralNucleoproteinsAntigen-antibody complex formation kineticsDiagnostics of COVID-19Optical biosensorsSARS-CoV-2Sars-CoV-2 nucleoproteinSurface plasmon resonanceTotal internal reflection ellipsometry (TIRE)

Identifiers

PMID33761394
PMCPMC7943374
OpenAlexW3134622612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.