Evidence map›Paper›PMID 33761345›Full record

ArticleCell reports2021

Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.

Kunwei Wu, Wenyan Han, Qingjun Tian, Yan Li, Wei Lu

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Restoration of Extrasynaptic/Synaptic GABANeuroscience bulletin · 2026
    Article
  2. Article
  3. Article
  4. Proteostasis regulation of GABABiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  5. Review
  6. Haploinsufficiency of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Shisa7-Dependent Regulation of GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  12. Shisa7 phosphorylation regulates GABAergic transmission and neurodevelopmental behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kunwei WuSynapse and Neural Circuit Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Wenyan HanSynapse and Neural Circuit Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Qingjun TianSynapse and Neural Circuit Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Yan LiProteomics Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Wei LuSynapse and Neural Circuit Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: luw4@mail.nih.gov.
National Institute of Neurological Disorders and Stroke · USNational Institutes of Health · US

Funding

The regulation of synaptic transmission and neural circuit functionZIANS003136 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI LU, WEI · 2012 to 2025
$27.0M
Intramural NIH HHS ZIA NS003136
6 · The paper itself

Abstract

Tonic inhibition mediated by extrasynaptic γ-aminobutyric acid type A receptors (GABA

Indexed as

AnimalsCyclic AMP-Dependent Protein KinasesExocytosisHEK293 CellsHippocampusHomeostasisHumansMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsNeural InhibitionNeuronsPhosphorylationProtein BindingCyclic AMP-Dependent Protein KinasesMembrane ProteinsNerve Tissue ProteinsReceptors, GABA-ASerineShisa7 protein, mouseexocytosisGABAGABA(A) receptorhomeostatic plasticityphosphorylationPKAShisa7sleep deprivationtonic inhibitionα5 subunit

Identifiers

PMID33761345
PMCPMC8025742
OpenAlexW3137922269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.