ArticleCell2021
Archaeogenomic distinctiveness of the Isthmo-Colombian area.
Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
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- Subsistence transition preceded population turnover in the eastern Colombian Andes.bioRxiv : the preprint server for biology · 2026Article
- Global patterns of natural selection inferred using ancient DNA.bioRxiv : the preprint server for biology · 2026Article
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- Fifteen millennia of human mitogenome evolution in Sicily.Science advances · 2025Article
- The origin of modern North Africans as depicted by a massive survey of mitogenomes.Scientific reports · 2025Article
- Tracing Human Diversity in South America's Southern Cone: Linguistic, Morphometric, and Genetic Perspectives.American journal of biological anthropology · 2025Article
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- A 6000-year-long genomic transect from the Bogotá Altiplano reveals multiple genetic shifts in the demographic history of Colombia.Science advances · 2025Article
- Urbanization and genetic homogenization in the medieval Low Countries revealed through a ten-century paleogenomic study of the city of Sint-Truiden.Genome biology · 2025Article
- Opportunities and challenges of local ancestry in genetic association analyses.American journal of human genetics · 2025Review
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- Biodistance Analysis via Dental Phenotypic Diversity in Early Collective Burials at Cerro Juan Díaz, Panamá (30-650 CE) [Análisis de Biodistancia Mediante la Diversidad Fenotípica Dental en los Entierros Colectivos Tempranos del Cerro Juan Díaz, Panamá (30-650 EC)].American journal of biological anthropology · 2025Article
- Improving data archiving practices in ancient genomics.Scientific data · 2024Article
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- A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children.Cell genomics · 2024Article
- Genomic analyses correspond with deep persistence of peoples of Blackfoot Confederacy from glacial times.Science advances · 2024Article
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Authors and funding
38 authors.
Funding
Abstract
The recently enriched genomic history of Indigenous groups in the Americas is still meager concerning continental Central America. Here, we report ten pre-Hispanic (plus two early colonial) genomes and 84 genome-wide profiles from seven groups presently living in Panama. Our analyses reveal that pre-Hispanic demographic events contributed to the extensive genetic structure currently seen in the area, which is also characterized by a distinctive Isthmo-Colombian Indigenous component. This component drives these populations on a specific variability axis and derives from the local admixture of different ancestries of northern North American origin(s). Two of these ancestries were differentially associated to Pleistocene Indigenous groups that also moved into South America, leaving heterogenous genetic footprints. An additional Pleistocene ancestry was brought by a still unsampled population of the Isthmus (UPopI) that remained restricted to the Isthmian area, expanded locally during the early Holocene, and left genomic traces up to the present day.
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