Evidence map›Paper›PMID 33761019›Full record

ArticleEJNMMI research2021

The pons as reference region for intensity normalization in semi-quantitative analysis of brain

A Verger, M Doyen, J Y Campion, Eric Guedj

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  7. Review
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  11. Age-related changes of human brain metabolism.European journal of nuclear medicine and molecular imaging · 2025
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  12. BrainEpilepsia · 2025
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  16. Basal forebrain activation improves working memory in senescent monkeys.bioRxiv : the preprint server for biology · 2024
    Article
  17. Article
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  20. Quantitative brainAnnals of clinical and translational neurology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

A VergerDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, 54000, Nancy, France.
M DoyenDepartment of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, 54000, Nancy, France.
J Y CampionCNRS, Ecole Centrale de Marseille, UMR 7249, Institut Fresnel, Aix-Marseille Université, Marseille, France.
Eric GuedjCNRS, Ecole Centrale de Marseille, UMR 7249, Institut Fresnel, Aix-Marseille Université, Marseille, France. eric.guedj@ap-hm.fr.ORCID http://orcid.org/0000-0003-1912-6132
Centre National de la Recherche Scientifique · FRInserm · FR

Funding

aphm PHRC 07 09
6 · The paper itself

Abstract

backgroundThe objective of the study is to define the most appropriate region for intensity normalization in brain

resultsThe cerebellum and pons were the two sole regions showing median coefficients of correlation with age less than - 0.5. With SPM, the intensity normalization by the pons provided at least 1.7- and 2.5-fold more significant cluster volumes than other normalizations for conventional and digital PET, respectively.

conclusionsThe pons is the most appropriate area for brain

Indexed as

18FDG PETAgeingBrainIntensity normalizationPonsSemi-quantitative analysis

Identifiers

PMID33761019
PMCPMC7990981
OpenAlexW3125027364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.