Evidence map›Paper›PMID 33760974›Full record

Observational studyClinical oral investigations2021

Clinical characterization of 266 patients and family members with cleft lip and/or palate with associated malformations and syndromes.

Theodosia Bartzela, Björn Theuerkauf, Elisabeth Reichardt, Malte Spielmann, Charlotte Opitz

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Theodosia BartzelaInstitute of Dental and Craniofacial Sciences, Dept. of Orthodontics, Dentofacial Orthopedics, and Pedodontics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Aßmannshauser Str. 4-6, 14197, Berlin, Germany. theodosia.bartzela@charite.de.ORCID http://orcid.org/0000-0001-8478-2078
Björn Theuerkauf, Ringpromenade 76, 14612 Falkensee, Berlin, Germany.
Elisabeth ReichardtKlinik für Pediatric Oral Health und Kieferorthopädie, Universitäres Zentrum für Zahnmedizin Basel, Mattenstrasse 40, 4058, Basel, Switzerland.
Malte SpielmannHuman Molecular Genomics Group, Max Planck Institute for Molecular Genetics, 13353, Berlin, Germany.
Charlotte OpitzInstitute of Dental and Craniofacial Sciences, Dept. of Orthodontics, Dentofacial Orthopedics, and Pedodontics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Aßmannshauser Str. 4-6, 14197, Berlin, Germany.
Humboldt-Universität zu Berlin · DEFaculdade de Agudos · BRMax Planck Institute for Molecular Genetics · DEUniversitäres Zentrum für Zahnmedizin Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo clinically characterize patients and family members with cleft lip and/or palate (CL/P) and associated congenital malformations or syndromes and propose possible inheritance patterns. MATERIALS AND

methodsAn observational study of patients with CL/P, including medical and family history and intra- and extra-oral examination of their family members, was performed.

resultsTwo hundred sixty-six patients, 1257 family members, and 42 pedigrees were included in the study. The distribution of patients according to the cleft type was 57.9% with CLP, 25.2% with cleft palate (CPO), and 12.8% with cleft lip with/without alveolus (CL/A). Seventy-four (27.8%) patients had associated malformations, and 24 (9.2%) a syndrome. The skeletal (27.7%), cardiovascular (19.3%) systems, and eyes (22.9%) were most commonly affected. Pierre Robin Sequence (7 patients) and van der Woude (4) were the most common syndromes. The majority of patients with CPO (19/24) had an associate syndrome. The families had an average of 2.45 affected members.

conclusionIndividual and interfamilial phenotypic variability in patients with CL/P makes the understanding of etiopathogenesis challenging. CLINICAL RELEVANCE: The overall prevalence of individuals with CL/P and their pedigrees with associated malformations and syndromes emphasize the need for early identification, interdisciplinary, and long-term planning.

Indexed as

Cleft LipCleft PalatePierre Robin SyndromeFamilyHumansAssociated anomaliesCleft lip and palateGeneticsPedigreesSyndromes

Identifiers

PMID33760974
PMCPMC8370934
OpenAlexW3139299141

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.