ArticlePloS one2021
Planning deficits in Huntington's disease: A brain structural correlation by voxel-based morphometry.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06976983 (Effects of Transcranial Static Magnetic Stimulation), which is not on this map. Cited by 4 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Transcranial Static Magnetic Stimulation (tSMS) in the Treatment of Hyperkinetic Symptoms of Huntington's Disease
Who cites it
4 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Intervention effect of a single exercise session on executive function in children and adolescents with attention deficit hyperactivity disorder: a three-level meta-analysis.BMC pediatrics · 2025Pooled it
- Effects of Exercise Training on Executive Functioning in Adults with Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Resting-state networks and their relationship with MoCA performance in PD patients.Brain imaging and behavior · 2024Article
- Functional Characterisation of the Circular RNA,Cells · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEarly Huntington's disease (HD) patients begin to show planning deficits even before motor alterations start to manifest. Generally, planning ability is associated with the functioning of anterior brain areas such as the medial prefrontal cortex. However, early HD neuropathology involves significant atrophy in the occipital and parietal cortex, suggesting that more posterior regions could also be involved in these planning deficits.
objectiveTo identify brain regions associated with planning deficits in HD patients at an early clinical stage. MATERIALS AND
methodsTwenty-two HD-subjects genetically confirmed with incipient clinical manifestation and twenty healthy subjects were recruited. All participants underwent MRI T1 image acquisition as well as testing in the Stockings of Cambridge (SOC) task to measure planning ability. First, group comparison of SOC measures were performed. Then, correlation voxel-based morphometry analyses were done between gray matter degeneration and SOC performance in the HD group.
resultsAccuracy and efficiency planning scores correlated with gray matter density in right lingual gyrus, middle temporal gyrus, anterior cingulate gyrus, and paracingulate gyrus.
conclusionsOur results suggest that planning deficits exhibited by early HD-subjects are related to occipital and temporal cortical degeneration in addition to the frontal areas deterioration.
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