Evidence map›Paper›PMID 33760644›Full record

ArticleJournal of neurophysiology2021

Transcranial direct current stimulation relieves visceral hypersensitivity via normalizing GluN2B expression and neural activity in anterior cingulate cortex.

Ying Xiao, Lei Xie, Qi-Ya Xu, Li Chen, Huan Chen, Guang-Yin Xu, Ping-An Zhang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ying XiaoSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Lei XieSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Qi-Ya XuJiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, People's Republic of China.
Li ChenSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Huan ChenSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Guang-Yin XuJiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, People's Republic of China.
Ping-An ZhangJiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, Soochow University, Suzhou, People's Republic of China.
University of Electronic Science and Technology of China · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Irritable bowel syndrome (IBS) is one of the most common challenging diseases for clinical treatment. The aim of this study is to investigate whether transcranial direct current stimulation (tDCS) has analgesic effect on visceral hypersensitivity (VH) in an animal model of IBS as well as the underlying mechanism. As the activation of GluN2B in anterior cingulate cortex (ACC) takes part in VH, we examined whether and how GluN2B in ACC takes part in the effect of tDCS. Neonatal maternal deprivation (NMD), a valuable experimental model to study the IBS pathophysiology, was used to induce visceral hypersensitivity of rats. We quantified VH as colorectal distention threshold and performed patch-clamp recordings of ACC neurons. The expression of GluN2B were determined by RT-qPCR and Western blotting. The GluN2B antagonist Ro 25-6981 was microinjected into the rostral and caudal ACC. tDCS was performed for 7 consecutive days. It was found that NMD decreased expression of GluN2B, which could be obviously reversed by tDCS. Injection of Ro 25-6981 into rostral and caudal ACC of normal rats induced VH and also reversed the analgesic effect of tDCS. Our data sheds light on the nonpharmacological therapy for chronic VH in pathological states such as IBS.

Indexed as

Transcranial Direct Current StimulationAnimalsAnimals, NewbornDisease Models, AnimalExcitatory Amino Acid AntagonistsGyrus CinguliHyperalgesiaIrritable Bowel SyndromeMalePatch-Clamp TechniquesPhenolsPiperidinesRatsRats, Sprague-DawleyReceptors, N-Methyl-D-AspartateVisceral PainExcitatory Amino Acid AntagonistsNR2B NMDA receptorPhenolsPiperidinesReceptors, N-Methyl-D-AspartateRo 25-6981analgesiaanterior cingulate cortexGluN2Btranscranial direct current stimulationvisceral hypersensitivity

Identifiers

PMID33760644
PMCPMC8356761
OpenAlexW3136088346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.