Evidence map›Paper›PMID 33760602›Full record

ArticleACS nano2021

Label-Free Ultrasensitive Detection of Abnormal Chiral Metabolites in Diabetes.

Yaoran Liu, Zilong Wu, Pavana Siddhartha Kollipara, Richard Montellano, Kumar Sharma, Yuebing Zheng

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 59 citations in OpenAlex.

  1. Review
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  6. Vibrational circular dichroism unveils hidden clues.Light, science & applications · 2023
    Article
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  9. Optothermal rotation of micro-/nano-objects.Chemical communications (Cambridge, England) · 2023
    Review
  10. Article
  11. Article
  12. Review
  13. Heat-Mediated Optical Manipulation.Chemical reviews · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yaoran LiuDepartment of Electrical and Computer Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.
Zilong WuWalker Department of Mechanical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-9323-7768
Pavana Siddhartha KolliparaWalker Department of Mechanical Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0003-0166-6720
Richard MontellanoCenter for Renal Precision Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78249, United States.
Kumar SharmaCenter for Renal Precision Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78249, United States.
Yuebing ZhengDepartment of Electrical and Computer Engineering, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0002-9168-9477
Walker (United States) · USThe University of Texas Health Science Center at San Antonio · USThe University of Texas at Austin · US

Funding

On-Chip Multiplexed Adhesion Frequency Assay for Measuring Receptor-Ligand Interactions on CellsDP2GM128446 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ZHENG, YUEBING · 2017 to 2017
$2.2M
NIGMS NIH HHS DP2 GM128446Shared Services Center NASA 80NSSC17K0520
6 · The paper itself

Abstract

Homochirality is necessary for normal biochemical processes in humans. Abnormal amounts of chiral molecules in biofluids have been found in patients with diabetes. However, the detailed analysis of diabetes-related abnormal chirality in biofluids and its potential use for clinical applications have been hindered by the difficulty in detecting and monitoring the chiral changes in biofluids, due to their low molar mass and trace concentrations. Herein, we demonstrate the label-free detection of chiral molecules using only 10 μL with 10

Indexed as

Diabetes MellitusAnimalsHumansMiceStereoisomerismaccumulationchiral metaboliteschiral metamaterialsdiabetesplasmonics

Identifiers

PMID33760602
PMCPMC8085063
OpenAlexW3138710331

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.