Evidence map›Paper›PMID 33760399›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2021

Association Between Gut Microbiota and Symptomatic Hand Osteoarthritis: Data From the Xiangya Osteoarthritis Study.

Jie Wei, Chenhong Zhang, Yuqing Zhang, Weiya Zhang, Michael Doherty, Tuo Yang, Guangju Zhai, Abasiama D Obotiba, Houchen Lyu, Chao Zeng and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
10.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Observational
  4. Review
  5. The complexity of pain in osteoarthritis.Nature reviews. Rheumatology · 2026
    Review
  6. The gut-joint axis in osteoarthritis.Nature reviews. Rheumatology · 2026
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Analysis of gut microbiota characteristics in osteoarthritis patients.Frontiers in cellular and infection microbiology · 2026
    Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Jie WeiHealth Management Center, Xiangya Hospital, Central South University, Changsha, China.
Chenhong ZhangState Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Yuqing ZhangDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, and the Mongan Institute, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-7638-0888
Weiya ZhangAcademic Rheumatology, Clinical Sciences Building, University of Nottingham, City Hospital, Nottingham, and Arthritis Research UK Pain Centre, Nottingham, UK.
Michael DohertyAcademic Rheumatology, Clinical Sciences Building, University of Nottingham, City Hospital, Nottingham, and Arthritis Research UK Pain Centre, Nottingham, UK.
Tuo YangHealth Management Center, Xiangya Hospital, Central South University, Changsha, China, Academic Rheumatology, Clinical Sciences Building, University of Nottingham, City Hospital, Nottingham, UK, and Arthritis Research UK Pain Centre, Nottingham, UK.
Guangju ZhaiDiscipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.ORCID 0000-0002-7263-0605
Abasiama D ObotibaAcademic Rheumatology, Clinical Sciences Building, University of Nottingham, City Hospital, Nottingham, and Arthritis Research UK Pain Centre, Nottingham, UK.ORCID 0000-0002-8818-032X
Houchen LyuDepartment of Orthopedics, General Hospital of Chinese PLA, Beijing, and Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China.
Chao ZengDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, and Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China.
Guanghua LeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, and Hunan Key Laboratory of Joint Degeneration and Injury, Changsha, China.ORCID 0000-0003-2987-138X
Central South University · CNUniversity of Nottingham · GBHarvard University · USMemorial University of Newfoundland · CAShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveSystemic inflammatory factors have been implicated in symptomatic hand osteoarthritis (OA). Gut microbiome dysbiosis promotes systemic inflammation. The aim of this study was to examine the association between the gut microbiome and the presence of symptomatic hand OA in a population-based study.

methodsStudy participants were subjects of the Xiangya Osteoarthritis Study, a community-based observational study conducted in the Hunan Province of China. Symptomatic hand OA was defined as the presence of both symptoms and radiographic OA in the same hand. The gut microbiome was analyzed using 16S ribosomal RNA gene sequencing in stool samples. We examined the relation of α-diversity, β-diversity, relative abundance of taxa, and potential bacterial functional pathways to symptomatic hand OA.

resultsA total of 1,388 participants (mean age 61.3 years, 57.4% women) were included in the study, of whom 72 had symptomatic hand OA (prevalence of symptomatic hand OA 5.2%). Beta-diversity of the gut microbiome, but not α-diversity, was significantly associated with the presence of symptomatic hand OA (P = 0.003). Higher relative abundance of the genera Bilophila and Desulfovibrio as well as lower relative abundance of the genus Roseburia was associated with symptomatic hand OA. Most functional pathways (i.e., those annotated in the KEGG Ortholog hierarchy) that were observed to be altered in participants with symptomatic hand OA belonged to the amino acid, carbohydrate, and lipid metabolic pathways.

conclusionThis large, population-based study provides the first evidence that alterations in the composition of the gut microbiome were observed among study participants who had symptomatic hand OA, and a low relative abundance of Roseburia but high relative abundance of Bilophila and Desulfovibrio at the genus level were associated with prevalent symptomatic hand OA. These findings may help investigators understand the role of the microbiome in the development of symptomatic hand OA and could contribute to potential translational opportunities.

Indexed as

AdultAgedFecesFemaleGastrointestinal MicrobiomeHand JointsHumansMaleMiddle AgedOsteoarthritisRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID33760399
PMCPMC8457181
OpenAlexW3137850759

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.