SynthesisCancer medicine2021
A systematic review and meta-analysis of the prognostic role of age in oral tongue cancer.
Synthesis in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.
- Prognostic factors in young patients with oral cavity cancer: a systematic review and meta-analysis of 24 studies.Frontiers in oncology · 2026Pooled it
- Advances in Oral Cavity Stem Cell Research Revealed through Multi-omics Analysis.Stem cell reviews and reports · 2026Review
- Early-Onset Oral Squamous Cell Carcinoma: Emerging Biological Insights, Risk Factors and Clinical Implications.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Review
- Age-Based Comparison of Head and Neck Cancer Characteristics and Reconstructive Outcomes: Retrospective Review of 286 Patients.Medicina (Kaunas, Lithuania) · 2026Article
- Tongue cancer in pregnancy: challenges and outcomes. A case series and review of the literature.Oral and maxillofacial surgery · 2025Review
- A Unique Plasma Protein Signature Characterizes Squamous Cell Carcinoma of the Oral Tongue in Young Adults.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025Article
- A SEER-based prognostic nomogram for early-stage (pT1-2N0M0) tongue squamous cell carcinoma and an observational analysis of postoperative radiotherapy.World journal of surgical oncology · 2025Observational
- A temporal and spatial analysis of incidence and mortality of lip, oral cavity, and pharyngeal cancer in a Northeastern Brazilian state.Scientific reports · 2025Article
- Spatiotemporal Dynamics in the Burden of Lip and Oral Cavity Cancer and Attributable Risk Factors in Asia (1990-2021).Healthcare (Basel, Switzerland) · 2025Article
- Long-term oncologic outcomes and prognostic factors related to recurrences in pathologic Stage I/II early oral tongue cancer.Frontiers in surgery · 2025Article
- Comparing clinicopathological profile and treatment outcomes in younger versus older patients with carcinoma oral tongue - a retrospective cohort study.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025Article
- Genetic Features of Tongue Cancer Recurrence in Young Adults.Bulletin of experimental biology and medicine · 2024Article
- Novel prognostic nomograms for postoperative patients with oral cavity squamous cell carcinoma in the central region of China.BMC cancer · 2024Article
- Trends in Oral Tongue Cancer Incidence in the US.JAMA otolaryngology-- head & neck surgery · 2024Article
- Survival among treated tongue cancer patients: a single-center experience.Discover oncology · 2024Article
- Contrasting clinical outcomes and socio-economic impact of young versus elderly-onset oral squamous cell carcinoma, a novel health economic analysis.Cancer medicine · 2024Article
- Oral cancer in young adults: incidence, risk factors, prognosis, and molecular biomarkers.Frontiers in oncology · 2024Review
- Treatment with (chemo)-radiation in old patients (≥76 years of age) with newly diagnosed non-metastatic squamous cell cancer of the head and neck region: real-world data from a tertiary referral center.Frontiers in oncology · 2024Article
- Tobacco- and alcohol-attributable burden of early-onset lip, oral cavity, and pharyngeal cancer in 204 countries and territories from 1990 to 2019, with projections to 2040.Frontiers in oncology · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While evidence suggests an increasing incidence of tongue cancer in young adults, published findings regarding the prognostic role of age at diagnosis are inconsistent. We performed a meta-analysis of the literature to highlight key points that might help in understanding the association between age of oral tongue cancer patients at diagnosis and their prognosis. According to age at diagnosis, a systematic literature review of all published cohort studies assessing the recurrence risks and mortality associated with tongue cancer was conducted. We compared the risk estimates between patients aged >45 years and those aged <45 years at diagnosis. Random-effects models were used to calculate summary relative risk estimates (SRRs) according to different clinical outcomes and sources of between-study heterogeneity (I
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.