Evidence map›Paper›PMID 33760152›Full record

ArticleMolecular medicine reports2021

Naringin ameliorates memory deficits and exerts neuroprotective effects in a mouse model of Alzheimer's disease by regulating multiple metabolic pathways.

Xiangdong Meng, Mingming Fu, Shoufeng Wang, Weida Chen, Jianjie Wang, Ning Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

  1. Naringin Reverses Chronic Stress-Induced Cognitive Deficits and Enhances Hippocampal Neuroplasticity in Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026
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  4. Evaluation of the Anti-Alzheimer Activity ofCurrent issues in molecular biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Xiangdong Meng *Nanchong Central Hospital, Second Clinical Medical College, Nanchong, Sichuan 637000, P.R. China.
Mingming Fu *Foreign Language Department, North Sichuan Medical College (University), Nanchong, Sichuan 637000, P.R. China.
Shoufeng WangAffiliated First Hospital, Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China.
Weida ChenAffiliated First Hospital, Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China.
Jianjie WangCollege of Basic Medicine, Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China.
Ning ZhangJiamusi College, College of Pharmacy, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang 154007, P.R. China.
First Affiliated Hospital of Jiamusi University · CNHeilongjiang University of Chinese Medicine · CNJiamusi University · CNNanchong Central Hospital · CNNorth Sichuan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the present study was to investigate the neuroprotective effects of naringin on the memory impairment of hydrocortisone mice, and to elucidate the potential underlying molecular mechanisms. In the present study, a hydrocortisone model was constructed. Novel object recognition, Morris water maze and step‑down tests were performed in order to assess the learning and memory abilities of mice. Hematoxylin and eosin staining was used to observe pathological changes in the hippocampus and hypothalamus. Transmission electron microscopy was used to observe the ultrastructural changes in the hippocampus. Immunohistochemistry was used to detect the expression of ERα and ERβ. Western blotting was performed to detect the expression of each protein in the relevant system. It was found that naringin can significantly improve cognitive, learning and memory dysfunction in mice with hydrocortisone memory impairment. In addition, naringin can exert neuroprotective effects through a variety of mechanisms, including amyloid β metabolism, Tau protein hyperphosphorylation, acetylcholinergic system, glutamate receptor system, oxidative stress and cell apoptosis. Naringin can also affect the expression of phosphorylated‑P38/P38, indicating that the neuroprotective effect of naringin may also involve the MAPK/P38 pathway. The results of the present study concluded that naringin can effectively improve the cognitive abilities of mice with memory impairment and exert neuroprotective effects. Thus, naringin may be a promising target drug candidate for the treatment of Alzheimer's disease.

Indexed as

Alzheimer DiseaseAnimalsDisease Models, AnimalFlavanonesHippocampusHumansMaze LearningMemory DisordersMetabolic Networks and PathwaysMiceNeuroprotective AgentsOxidative Stressp38 Mitogen-Activated Protein KinasesPhosphorylationtau ProteinsFlavanonesMapt protein, mousenaringinNeuroprotective Agentsp38 Mitogen-Activated Protein Kinasestau ProteinsAlzheimer's diseaseamyloid‑βapoptosismemory impairmentnaringin

Identifiers

PMID33760152
PMCPMC7974313
OpenAlexW3134944333

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.