Evidence map›Paper›PMID 33760132›Full record

ArticleMolecular medicine reports2021

HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells

Dongjie Sun, Zhehao Huang, Jinying Xu, Yiqing Wang, Lin Chen, Yi Hou, Guangfan Chi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. The Central Roles of Keratinocytes in Coordinating Skin Immunity.The Journal of investigative dermatology · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Frontiers in physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Dongjie SunThe Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130000, P.R. China.
Zhehao HuangDepartment of Neurosurgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130000, P.R. China.
Jinying XuThe Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130000, P.R. China.
Yiqing WangDepartment of Genetics, Basic Medical College of Jilin University, Changchun, Jilin 130000, P.R. China.
Lin ChenThe Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130000, P.R. China.
Yi HouDepartment of Regeneration Medicine, School of Pharmaceutical Science of Jilin University, Changchun, Jilin 130000, P.R. China.
Guangfan ChiThe Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130000, P.R. China.
Jilin University · CNJilin Medical University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hair loss, including alopecia, is a common and distressing problem for men and women, and as a result, there is considerable interest in developing treatments that can prevent or reverse hair loss. Dermal papillae closely interact with epidermal cells and play a key role during hair follicle induction and hair morphogenesis. As dermal papilla cells (DPCs) lose their hair‑inducing ability in monolayer cultures

Indexed as

AlopeciaBenzamidesCell Culture TechniquesCell DedifferentiationCulture Media, ConditionedDermisDioxolesHairHair FollicleHumansKeratinocytesPlatelet-Derived Growth FactorPyridinesPyrimidinesSmall Molecule LibrariesWnt Signaling Pathway4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideBenzamidesChir 99021Culture Media, ConditionedDioxolesPlatelet-Derived Growth Factorplatelet-derived growth factor APyridinesPyrimidinesSmall Molecule Librariesdedifferentiationdermal papilla cellsHaCaT cellshair follicle regenerationsmall molecule inhibitorsthree‑dimensional culture

Identifiers

PMID33760132
PMCPMC7974413
OpenAlexW3135813227

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.