Evidence map›Paper›PMID 33759764›Full record

ArticleeLife2021

Pregnancy-associated plasma protein-aa regulates endoplasmic reticulum-mitochondria associations.

Mroj Alassaf, Mary C Halloran

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Mroj AlassafDepartment of Integrative Biology, University of Wisconsin, Madison, United States.ORCID 0000-0001-6277-9417
Mary C HalloranDepartment of Integrative Biology, University of Wisconsin, Madison, United States.ORCID 0000-0001-6086-5928
University of Wisconsin–Madison · US

Funding

Ministry of Education - Kingdom of Saudi Arabi Graduate Student FellowshipMinistry of Education Saudi Arabia Graduate Student FellowshipUniversity of Wisconsin-Madison UW internal fundsUW-Madison graduate support funds UW internal funds
6 · The paper itself

Abstract

Endoplasmic reticulum (ER) and mitochondria form close physical associations to facilitate calcium transfer, thereby regulating mitochondrial function. Neurons with high metabolic demands, such as sensory hair cells, are especially dependent on precisely regulated ER-mitochondria associations. We previously showed that the secreted metalloprotease pregnancy-associated plasma protein-aa (Pappaa) regulates mitochondrial function in zebrafish lateral line hair cells (Alassaf et al., 2019). Here, we show that

Indexed as

AnimalsCalciumEndoplasmic ReticulumEndoplasmic Reticulum StressHair Cells, Auditory, InnerLateral Line SystemMetalloendopeptidasesMicroscopy, Electron, Scanning TransmissionMitochondriaZebrafishZebrafish ProteinsCalciumMetalloendopeptidasespappaa protein, zebrafishZebrafish Proteinsautophagycell biologyER stresshair cellIGF signalingneurodegenerationneurosciencezebrafish

Identifiers

PMID33759764
PMCPMC8024009
OpenAlexW3139264039

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.