ArticleeLife2021
Network dynamics underlying OFF responses in the auditory cortex.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Data-Constrained Recurrent Network Neural Model Uncovers the Circuit Mechanism of Olfactory OFF Responses.bioRxiv : the preprint server for biology · 2026Article
- Computing the effects of excitatory-inhibitory balance on neuronal input-output properties.PLoS computational biology · 2026Article
- The representation of omitted sounds in the mouse auditory cortex.Nature communications · 2026Article
- Identification of Distinct Topological Structures From High-Dimensional Data.bioRxiv : the preprint server for biology · 2025Article
- Slow Transition to Low-Dimensional Chaos in Heavy-Tailed Recurrent Neural Networks.bioRxiv : the preprint server for biology · 2025Article
- Article
- The what, which, when, why and who of Off responses in the auditory system.The Journal of physiology · 2025Review
- Novel Verbal Instructions Recruit Abstract Neural Patterns of Time-Variable Information Dimensionality.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Dissociative and prioritized modeling of behaviorally relevant neural dynamics using recurrent neural networks.Nature neuroscience · 2024Article
- A general model unifying the adaptive, transient and sustained properties of ON and OFF auditory neural responses.PLoS computational biology · 2024Article
- Neuronal travelling waves explain rotational dynamics in experimental datasets and modelling.Scientific reports · 2024Article
- Dynamical flexible inference of nonlinear latent factors and structures in neural population activity.Nature biomedical engineering · 2024Article
- Early selection of task-relevant features through population gating.Nature communications · 2023Article
- A robust and compact population code for competing sounds in auditory cortex.Journal of neurophysiology · 2023Article
- Quantitative models of auditory cortical processing.Hearing research · 2023Review
- Relating local connectivity and global dynamics in recurrent excitatory-inhibitory networks.PLoS computational biology · 2023Article
- More than the end: OFF response plasticity as a mnemonic signature of a sound's behavioral salience.Frontiers in computational neuroscience · 2022Review
- Article
- Interrogating theoretical models of neural computation with emergent property inference.eLife · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Across sensory systems, complex spatio-temporal patterns of neural activity arise following the onset (ON) and offset (OFF) of stimuli. While ON responses have been widely studied, the mechanisms generating OFF responses in cortical areas have so far not been fully elucidated. We examine here the hypothesis that OFF responses are single-cell signatures of recurrent interactions at the network level. To test this hypothesis, we performed population analyses of two-photon calcium recordings in the auditory cortex of awake mice listening to auditory stimuli, and compared them to linear single-cell and network models. While the single-cell model explained some prominent features of the data, it could not capture the structure across stimuli and trials. In contrast, the network model accounted for the low-dimensional organization of population responses and their global structure across stimuli, where distinct stimuli activated mostly orthogonal dimensions in the neural state-space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.