Evidence map›Paper›PMID 33759579›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2021

The developing murine lung is susceptible to acetaminophen toxicity.

Evgenia Dobrinskikh, Laura G Sherlock, David J Orlicky, Lijun Zheng, Robyn De Dios, Durga Balasubramaniyan, Thom Sizemore, Brittany Butler, Clyde J Wright

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. TLR9-mediated innate immune signaling contributes to acetaminophen-induced injury in the developing lung.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  4. Article
  5. Article
  6. A Single Early-Life Acetaminophen Exposure Causes Persistent Abnormalities in the Murine Lung.American journal of respiratory cell and molecular biology · 2025
    Article
  7. The potential of curcumin in mitigating acetaminophen-induced liver damage.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  8. Article
  9. Article
  10. Associations between cord blood acetaminophen biomarkers and childhood asthma with and without allergic comorbidities.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Article
  11. Acetaminophen for the patent ductus arteriosus: has safety been adequately demonstrated?Journal of perinatology : official journal of the California Perinatal Association · 2023
    Review
  12. Review
  13. Article
  14. Pulmonary implications of acetaminophen exposures independent of hepatic toxicity.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Evgenia DobrinskikhSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Laura G SherlockSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
David J OrlickyDepartment of Pathology, University of Colorado School of Medicine, Aurora, Colorado.ORCID 0000-0002-0417-1400
Lijun ZhengSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Robyn De DiosSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Durga BalasubramaniyanSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Thom SizemoreSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Brittany ButlerSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
Clyde J WrightSection of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado.
University of Colorado Denver · US

Funding

Role of hepatic IkBb-mediated sustained NFkB activation in neonatal lung injury and abnormal developmentR01HL132941 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI WRIGHT, CLYDE JASON · 2017 to 2021
$2.3M
NHLBI NIH HHS R01 HL132941
6 · The paper itself

Abstract

Acetaminophen (

Indexed as

AcetaminophenAnimalsCytochrome P-450 CYP2E1Gene Expression Regulation, EnzymologicGlycolysisLungLung InjuryMaleMiceOxidative PhosphorylationAcetaminophencytochrome P-450 2E1, mouseCytochrome P-450 CYP2E1acetaminophenCYP2E1liver injurylung injuryneonateparacetamol

Identifiers

PMID33759579
PMCPMC8174833
OpenAlexW3139499680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.