ArticleEnvironmental science & technology2021
Feasibility of Lead Exposure Assessment in Blood Spots using Energy-Dispersive X-ray Fluorescence.
Article in Environmental science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Energy dispersive X-ray fluorescence provides a new option for measuring arsenic, mercury, and lead in dried blood spots.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2026Article
- Comparison between inductively coupled plasma-mass spectrometry and benchtop X-ray fluorescence performance for trace elemental exposure in rat tissues.Journal of trace elements and minerals · 2025Article
- Lead Toxicity and Maternal Exposure: Characterisation of Alveolar Bone Changes on Offspring Rats.Biological trace element research · 2025Article
- Elevated Metal Levels in U.S. Honeys: Is There a Concern for Human Health?Biological trace element research · 2025Article
- Ways to Measure Metals: From ICP-MS to XRF.Current environmental health reports · 2025Review
- Portable x-ray fluorescence for bone lead measurement: Current approaches and future directions.Current environmental health reports · 2024Review
- Benchtop x-ray fluorescence to quantify elemental content in nails non-destructively.The Science of the total environment · 2024Article
- A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots.Journal of exposure science & environmental epidemiology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Collecting blood spots from newborns is a common procedure used to diagnose multiple health conditions. Fingerstick blood samples are routinely collected from children to diagnose elevated blood lead levels. In our study, we wanted to test the feasibility of using a high-power energy-dispersive X-ray fluorescence (EDXRF) device to accurately measure the concentration of lead in blood spots. We created spotted standards of a known concentration of lead on a filter paper at different volumes and concentrations. We determined the detection limit for lead through repeated measurements of our standards and calibration line slopes. We also tested the variability of the measured lead concentration across procedures and spotted blood volumes and found no significant additions to uncertainty in measurements. Finally, we compared blood lead concentrations measured by EDXRF and atomic absorption spectroscopy (AAS) and found EDXRF to be a significant predictor of blood lead (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.