ArticleObesity (Silver Spring, Md.)2021
Describing the Weight-Reduced State: Physiology, Behavior, and Interventions.
Article in Obesity (Silver Spring, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Pooled it
- Obesity in Adults: A 2022 Adapted Clinical Practice Guideline for Ireland.Obesity facts · 2022Guideline
- Orforglipron for maintenance of body weight reduction: the double-blind, randomized phase 3b ATTAIN-MAINTAIN trial.Nature medicine · 2026 · on this mapTrial
- Efficacy and Safety of Tirzepatide in Japanese Participants With Obesity: A Subpopulation Analysis of the SURMOUNT-1 Trial.Obesity (Silver Spring, Md.) · 2026Trial
- One Year of Exercise After Weight Loss Increases Postprandial GLP-1 Secretion in Contrast to Usual Activity or GLP-1 Receptor Agonist Treatment.Obesity (Silver Spring, Md.) · 2026Trial
- Effect of physical activity on changes in weight and aerobic capacity during an 18-month behavioral weight loss intervention.The international journal of behavioral nutrition and physical activity · 2025Trial
- Enhancing performance through biochemical monitoring and nutritional support in female weightlifters during pre-competition weight reduction: a randomized trial.Journal of the International Society of Sports Nutrition · 2024Trial
- Switching diets after 6-months does not result in renewed weight loss: a secondary analysis of a 12-month crossover randomized trial.Scientific reports · 2024Trial
- The relationship between psychological distress and weight maintenance in weight cycling: mediating role of eating behavior.BMC public health · 2024Trial
- Effects of a 4-month active weight loss phase followed by weight loss maintenance on adaptive thermogenesis in resting energy expenditure in former elite athletes.European journal of nutrition · 2022Trial
- Mediators of weight change in underserved patients with obesity: exploratory analyses from the Promoting Successful Weight Loss in Primary Care in Louisiana (PROPEL) cluster-randomized trial.The American journal of clinical nutrition · 2022Trial
- The Physiology Of the WEight Reduced State (POWERS) study: overview and study design.International journal of obesity (2005) · 2026Review
- The Physiology Of the WEight Reduced State (POWERS) study: strategies for the analysis of biological specimens.International journal of obesity (2005) · 2026Article
- Unpacking adiposity: a narrative critical appraisal of diverse obesity definitions.Diabetology & metabolic syndrome · 2026Review
- Weight Loss Plateau: Reasons, Challenges, and Solutions: A Narrative Review.Health science reports · 2026Article
- Weight stigma in Latin America and the Caribbean: regional evidence and a call to action by ABESO.Lancet regional health. Americas · 2026Review
- Adherence to Behavioral Weight Management: A Scoping Review of Definitions, Measurement, and Components.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Article
- Mechanisms of weight recurrence after bariatric surgery.Nutrition & metabolism · 2026Review
- Post-operative Metabolic Adaptation and its Influence on Long-Term Recurrent Weight Gain After Metabolic and Bariatric Surgery.Obesity surgery · 2026Article
- Classification of Obesity Based on Weight History: Perceptions of People With Obesity.Clinical obesity · 2026Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
Although many persons with obesity can lose weight by lifestyle (diet and physical activity) therapy, successful long-term weight loss is difficult to achieve, and most people who lose weight regain their lost weight over time. The neurohormonal, physiological, and behavioral factors that promote weight recidivism are unclear and complex. The National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop in June 2019, titled "The Physiology of the Weight-Reduced State," to explore the mechanisms and integrative physiology of adaptations in appetite, energy expenditure, and thermogenesis that occur in the weight-reduced state and that may oppose weight-loss maintenance. The proceedings from the first session of this workshop are presented here. Drs. Michael Rosenbaum, Kevin Hall, and Rudolph Leibel discussed the physiological factors that contribute to weight regain; Dr. Michael Lowe discussed the biobehavioral issues involved in weight-loss maintenance; Dr. John Jakicic discussed the influence of physical activity on long-term weight-loss maintenance; and Dr. Louis Aronne discussed the ability of drug therapy to maintain weight loss.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.