Evidence map›Paper›PMID 33759054›Full record

Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Low blood caspase-8 levels in survivor patients of traumatic brain injury.

Leonardo Lorente, María M Martín, Antonia Pérez-Cejas, Agustín F González-Rivero, Luis Ramos-Gómez, Jordi Solé-Violán, Juan J Cáceres, Carmen Ferrer-Moure, Alejandro Jiménez

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Leonardo LorenteIntensive Care Unit, Hospital Universitario de Canarias, Ofra s/n La Laguna, 38320, Santa Cruz de Tenerife, Spain. lorentemartin@msn.com.ORCID http://orcid.org/0000-0003-4902-4065
María M MartínIntensive Care Unit, Hospital Universitario Nuestra Señora de Candelaria, Crta del Rosario s/n, 38010, Santa Cruz de Tenerife, Spain.
Antonia Pérez-CejasLaboratory Department, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Agustín F González-RiveroLaboratory Department, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Luis Ramos-GómezIntensive Care Unit, Hospital General de La Palma, Buenavista de Arriba s/n, 38713, Breña Alta, La Palma, Spain.
Jordi Solé-ViolánIntensive Care Unit, Hospital Universitario Dr. Negrín, CIBERES Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain.
Juan J CáceresIntensive Care Unit, Hospital Insular, Plaza Dr. Pasteur s/n, 35016, Las Palmas de Gran Canaria, Spain.
Carmen Ferrer-MoureLaboratory Department, Hospital Universitario de Canarias, Ofra, s/n. La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Alejandro JiménezResearch Unit, Hospital Universitario de Canarias, Ofra s/n La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Hospital Universitario de Canarias · ESHospital Universitario de Gran Canaria Doctor Negrín · ESHospital Universitario Insular de Gran Canaria · ESHospital Universitario Nuestra Señora de Candelaria · ES

Funding

Instituto de Salud Carlos III (ES) PI-18-00500
6 · The paper itself

Abstract

objectiveHigh concentrations of caspase-8 (main initiator caspase of the extrinsic pathway of apoptosis) have been found in brain tissue of patients with traumatic brain injury (TBI) and in the blood of patients with different diseases. However, blood caspase-8 concentrations in TBI patients have not been reported. Therefore, our aim was to analyze whether blood caspase-8 concentrations are associated with mortality in TBI patients.

methodPatients with isolated and severe TBI were included. TBI was considered isolated if it showed an Injury Severity Score (ISS) <10 points on non-cranial aspects. TBI was considered severe if it showed a Glasgow Coma Scale (GCS) <9 points. This prospective observational study was conducted in 5 Intensive Care Units. Serum caspase-8 concentrations were measured on day 1 of TBI.

resultsSurviving patients (n=59) had lower age (p=0.004), higher GCS (p=0.001), lower APACHE-II score (p<0.001), lower high-risk-of-death computed tomography (CT) findings (p=0.02), lower intracranial pressure (ICP) (p=0.01), and lower serum caspase-8 concentrations (p<0.001) than non-surviving patients (n=24). An association was found between serum caspase-8 levels and mortality after controlling for CT findings, GCS, and age (OR=1.037; 95% CI=1.013-1.062; p=0.002), and after controlling for CT findings, APACHE-II, and ICP (OR=1.042; 95% CI=1.013-1.071; p=0.004) in multiple logistic regression.

conclusionsTo our knowledge, this is the first series describing blood caspase-8 concentrations in patients with TBI. The association of high blood caspase-8 concentrations with mortality was the main new finding of the study. However, further investigations are needed to validate the preliminary results of our study.

Indexed as

Brain InjuriesBrain Injuries, TraumaticCaspase 8Glasgow Coma ScaleHumansSurvivorsCaspase 8BrainCaspase-8InjuryMortalityPatientsTrauma

Identifiers

PMID33759054
OpenAlexW3138904048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.