Evidence map›Paper›PMID 33758972›Full record

ArticlePsychopharmacology2021

Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice.

Kristyn N Borrelli, Carly R Langan, Kyra R Dubinsky, Karen K Szumlinski, William A Carlezon, Elena H Chartoff, Camron D Bryant

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Kristyn N BorrelliLaboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry, Boston University School of Medicine, 72 E. Concord St, L-606C, Boston, MA, 02118, USA.
Carly R LanganLaboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry, Boston University School of Medicine, 72 E. Concord St, L-606C, Boston, MA, 02118, USA.
Kyra R DubinskyLaboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry, Boston University School of Medicine, 72 E. Concord St, L-606C, Boston, MA, 02118, USA.
Karen K SzumlinskiDepartment of Psychological and Brain Sciences; Department of Molecular, Cellular and Developmental Biology; and the Neuroscience Research Institute, University of California, Santa Barbara, CA, USA.
William A CarlezonDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.
Elena H ChartoffDepartment of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA, USA.
Camron D BryantLaboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry, Boston University School of Medicine, 72 E. Concord St, L-606C, Boston, MA, 02118, USA. camron@bu.edu.ORCID http://orcid.org/0000-0003-4505-5809
Boston University · USHarvard University · USUniversity of California, Santa Barbara · US

Funding

TRAINING IN BIOMOLECULAR PHARMACOLOGYT32GM008541 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FARB, DAVID H · 1997 to 2022
$5.2M
A Reduced Complexity Cross in BALB/c substrains to identify the genetic basis of oxycodone dependence phenotypesU01DA050243 · NIDA · NORTHEASTERN UNIVERSITY · PI BRYANT, CAMRON D, ZACHARIOU, VENETIA · 2020 to 2023
$3.3M
Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in miceR01DA039168 · NIDA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BRYANT, CAMRON D · 2015 to 2019
$3.0M
Burroughs Wellcome Fund 1011479NIDA NIH HHS R01 DA039168NIDA NIH HHS U01 DA050243NIDA NIH HHS U01DA050243NIGMS NIH HHS GM008541NIGMS NIH HHS T32 GM008541
6 · The paper itself

Abstract

rationaleMethamphetamine (MA) addiction is a major public health issue in the USA, with a poorly understood genetic component. We previously identified heterogeneous nuclear ribonucleoprotein H1 (Hnrnph1; H1) as a quantitative trait gene underlying sensitivity to MA-induced behavioral sensitivity. Mice heterozygous for a frameshift deletion in the first coding exon of H1 (H1

objectivesWe examined innate reward sensitivity and facilitation by MA in H1

methodsWe used intracranial self-stimulation (ICSS) of the medial forebrain bundle to assess shifts in reward sensitivity following acute, ascending doses of MA (0.5-4.0 mg/kg, i.p.) using a within-subjects design. We also assessed video-recorded behaviors during ICSS testing sessions.

resultsH1

conclusionsH1

Indexed as

RewardAnimalsDopamine AgentsDose-Response Relationship, DrugFemaleHeterogeneous-Nuclear RibonucleoproteinsLocomotionMaleMedial Forebrain BundleMethamphetamineMiceMice, Inbred C57BLMice, TransgenicSelf AdministrationSelf StimulationDopamine AgentsHeterogeneous-Nuclear RibonucleoproteinsHnrnph1 protein, mouseMethamphetamineAddictionBehavioral geneticsForward geneticsGeneticsIntracranial self-stimulation (ICSS)MethamphetamineMousePsychostimulantsQTLSensitization

Identifiers

PMID33758972
PMCPMC8715365
OpenAlexW3137055940

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.