ArticleLangenbeck's archives of surgery2021
Delayed post-pancreatectomy hemorrhage and bleeding recurrence after percutaneous endovascular treatment: risk factors from a bi-centric study of 307 consecutive patients.
Article in Langenbeck's archives of surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- A predictive model for postoperative hemorrhage in patients with clinically relevant pancreatic fistula following minimally invasive pancreaticoduodenectomy.Surgical endoscopy · 2026Article
- Elevated Liver Enzymes Can Predict Complications Early After Pancreatic Resection.Journal of clinical medicine · 2026Article
- Stent-graft implantation for late postpancreatectomy hemorrhage after pancreatoduodenectomy.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Hemoglobin loss method calculates blood loss during pancreaticoduodenectomy and predicts bleeding-related risk factors.World journal of gastrointestinal surgery · 2024Article
- Wrapping gastroduodenal artery stump with the teres hepatis ligament to prevent postpancreatectomy hemorrhage after pancreaticoduodenectomy.World journal of surgical oncology · 2023Article
- Endovascular treatment for delayed post-pancreaticoduodenectomy hemorrhage of unusual origin (splenic artery branch).Journal of vascular surgery cases and innovative techniques · 2022Article
- Efficacy and safety of endovascular therapy for delayed hepatic artery post-pancreatectomy hemorrhage: development of extrahepatic collateral circulation and complications of post endovascular therapy.CVIR endovascular · 2022Article
- Preoperative NLR and PLR are predictive of clinically relevant postoperative pancreatic fistula.Surgery in practice and science · 2022Article
- Confusing delayed hematemesis, unusual arterial hemorrhage after pancreaticoduodenectomy: a case report.The Journal of international medical research · 2022Article
- Incidence and Contemporary Management of Delayed Bleeding Following Pancreaticoduodenectomy.World journal of surgery · 2022Article
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10 authors at 2 institutions in 1 country.
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Abstract
purposeDelayed post-pancreatectomy hemorrhage (PPH) is still one of the most dreaded complications after pancreatic surgery. Its management is now focused on percutaneous endovascular treatments (PETs).
methodsBetween 2013 and 2019, 307 patients underwent pancreatic resection. The first endpoint of this study was to determine predictive factors of delayed PPH. The second endpoint was to describe the management of intra-abdominal abscesses (IAA). The third endpoint was to identify risk factors of bleeding recurrence after PET. Patients were divided into two cohorts: A retrospective analysis was performed ("cohort 1," "learning set") to highlight predictive factors of delayed PPH. Then, we validated it on a prospective maintained cohort, analyzed retrospectively ("cohort 2," "validation set"). Second and third endpoints studies were made on the entire cohort.
resultsIn cohort 1, including 180 patients, 24 experienced delayed PPH. Multivariate analysis revealed that POPF diagnosis on postoperative day (POD) 3 (p=0.004) and IAA (p=0.001) were independent predictive factors of delayed PPH. In cohort 2, association of POPF diagnosis on POD 3 and IAA was strongly associated with delayed PPH (area under the curve [AUC] 0.80; 95% confidence interval [CI] [0.59-0.94]; p=0.003). Concerning our second endpoint, delayed PPH occurred less frequently in patients who underwent postoperative drainage procedure than in patients without IAA drainage (p=0.002). Concerning our third endpoint, a higher body mass index (BMI) (p=0.027), occurrence of postoperative IAA (p=0.030), and undrained IAA (p=0.011) were associated with bleeding recurrence after the first PET procedure.
conclusionPOPF diagnosis on POD 3 and intra-abdominal abscesses are independent predictive factors of delayed PPH. Therefore, patients presenting an insufficiently drained POPF leading to intra-abdominal abscess after pancreatic surgery should be considered as a high-risk situation of delayed PPH. High BMI, occurrence of postoperative IAA, and undrained IAA were associated with recurrence of bleeding after PET.
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