Evidence map›Paper›PMID 33758823›Full record

ArticleBrain communications2021

Implication of sestrin3 in epilepsy and its comorbidities.

Francesca Lovisari, Paolo Roncon, Marie Soukoupova, Giovanna Paolone, Marilyne Labasque, Selene Ingusci, Chiara Falcicchia, Pietro Marino, Michael Johnson, Tiziana Rossetti and 7 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. The functions and roles of sestrins in regulating human diseases.Cellular & molecular biology letters · 2022
    Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 4 countries.

Francesca LovisariDepartment of Medical Sciences, Section of Pharmacology, University of Ferrara, Italy.
Paolo RonconDivision of Neuroscience, School of Medicine, University Vita-Salute San Raffaele, Milan, Italy.
Marie SoukoupovaDepartment of Medical Sciences, Section of Pharmacology, University of Ferrara, Italy.
Giovanna PaoloneDepartment of Medical Sciences, Section of Pharmacology, University of Ferrara, Italy.
Marilyne LabasqueDepartment of Medical Sciences, Section of Pharmacology, University of Ferrara, Italy.
Selene IngusciDepartment of Medical Sciences, Section of Pharmacology, University of Ferrara, Italy.
Chiara FalcicchiaDepartment of Medical Sciences, Section of Pharmacology, University of Ferrara, Italy.
Pietro MarinoDepartment of Medical Sciences, Section of Pharmacology, University of Ferrara, Italy.
Michael JohnsonDivision of Brain Sciences, Imperial College London, UK.
Tiziana RossettiDivision of Brain Sciences, Imperial College London, UK.
Enrico PetrettoProgramme in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore.
Karine LeclercqNeuroscience TA, UCB Biopharma SPRL, Braine l'Alleud, Belgium.
Rafal M KaminskiNeuroscience TA, UCB Biopharma SPRL, Braine l'Alleud, Belgium.
Ben MoyonEs Cell and Transgenics, Medical Research Council, Imperial College London, UK.
Zoe WebsterEs Cell and Transgenics, Medical Research Council, Imperial College London, UK.
Michele SimonatoDepartment of Medical Sciences, Section of Pharmacology, University of Ferrara, Italy.
Silvia ZucchiniDepartment of Medical Sciences, Section of Pharmacology, University of Ferrara, Italy.
University of Ferrara · ITImperial College London · GBUCB Pharma (Belgium) · BEVita-Salute San Raffaele University · ITMedical Research Council · GBMRC London Institute of Medical Sciences · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is a serious neurological disorder affecting about 1% of the population worldwide. Epilepsy may arise as a result of acquired brain injury, or as a consequence of genetic predisposition. To date, genome-wide association studies and exome sequencing approaches have provided limited insights into the mechanisms of acquired brain injury. We have previously reported a pro-epileptic gene network, which is conserved across species, encoding inflammatory processes and positively regulated by sestrin3 (SESN3). In this study, we investigated the phenotype of

Indexed as

anxietydepressionepilepsysestrins

Identifiers

PMID33758823
PMCPMC7966953
OpenAlexW3092161845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.