ArticleEClinicalMedicine2021
COPD and the risk of poor outcomes in COVID-19: A systematic review and meta-analysis.
Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06189196 (Effects of Blow Bottle Verses ACBTs Technique in Patients of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 170 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Blow Bottle Verses ACBTs Technique in Patients of Chronic Obstructive Pulmonary Disease
Who cites it
170 citing papers in PubMed, 3 syntheses or guidelines pooled it, 288 citations in OpenAlex.
- Prevalence and incidence of chronic obstructive pulmonary disease in Latin America and the Caribbean: a systematic review and meta-analysis.BMC pulmonary medicine · 2022Pooled it
- Factors associated with COVID-19 in people with Parkinson's disease: a systematic review and meta-analysis.European journal of neurology · 2021Pooled it
- Reduction in hospitalised COPD exacerbations during COVID-19: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Disentangling Shared and Differential Genetic Architectures Between COVID-19 and Other Respiratory Disorders-A Genome-Wide Multi-Omics Framework.International journal of molecular sciences · 2026Article
- Risk factors for mechanical ventilation and mortality among hospitalized Medicaid patients with COVID-19 in Kentucky, 2020-2021.Scientific reports · 2026Article
- Risk factors associated with chronic obstructive pulmonary disease severity among adults: a hospital-based cross-sectional study in Ningbo, China (2022-2025).Journal of thoracic disease · 2026Article
- Human iPSC-derived airway models enable comparative analysis of SARS-CoV-2 infection in healthy and COPD bronchial epithelium.iScience · 2026Article
- Article
- The Impact of COVID-19 on Obstructive Pulmonary Diseases: A Narrative Review of Long-Term Consequences and Vaccination Strategies.Health science reports · 2026Article
- Expiratory Muscle Strength Training in COPD Dysphagia Management: A Survey of Speech-Language Pathologists.Journal of clinical medicine · 2026Article
- COVID-19 outcomes in individuals with severe alpha-1 antitrypsin deficiency in Sweden.Scientific reports · 2026Article
- Safety and antibody responses to inactivated COVID-19 vaccines among elderly patients with COPD: a prospective cohort study.Frontiers in immunology · 2026Article
- The contributions of active and passive smoking to COPD-related mortality and DALYs in the context of COVID-19: Global Burden 2019-2021.Tobacco induced diseases · 2026Article
- Article
- Expression of SARS-CoV-2 entry-associated proteins in COPD airways: an immunohistochemical study.The Journal of pathology · 2025Article
- Delay in lung volume reduction surgery due to the COVID-19 pandemic: impact on patient performance and mortality.Journal of thoracic disease · 2025Article
- Sex-based differences in mortality among a large cohort of hospitalized patients with RT-PCR-confirmed SARS-CoV-2 infection at five different pandemic waves in Northern Iran.Scientific reports · 2025Article
- Distal lung organoids derived from adult stem cells as novel tools in deciphering mechanisms of lung regeneration, infection, and cancer.Stem cells translational medicine · 2025Review
- Article
- Factors associated with cross infections in COVID-19 patients in a Tunisian intensive care unit: a longitudinal study.BMC infectious diseases · 2025Observational
110 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with chronic obstructive pulmonary disease (COPD) are highly susceptible from respiratory exacerbations from viral respiratory tract infections. However, it is unclear whether they are at increased risk of COVID-19 pneumonia or COVID-19-related mortality. We aimed to determine whether COPD is a risk factor for adverse COVID-19 outcomes including hospitalization, severe COVID-19, or death.
methodsFollowing the PRISMA guidelines, we performed a systematic review of COVID-19 clinical studies published between November 1
findingsFifty-nine studies met the inclusion criteria, and underwent data extraction. Most studies were retrospective cohort studies/case series of hospitalized patients. Only four studies examined the effects of COPD on COVID-19 outcomes as their primary endpoint. In aggregate, COPD was associated with increased odds of hospitalization (OR 4.23, 95% confidence interval [CI] 3.65-4.90), ICU admission (OR 1.35, 95% CI 1.02-1.78), and mortality (OR 2.47, 95% CI 2.18-2.79).
interpretationHaving a clinical diagnosis of COPD significantly increases the odds of poor clinical outcomes in patients with COVID-19. COPD patients should thus be considered a high-risk group, and targeted for preventative measures and aggressive treatment for COVID-19 including vaccination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.