Evidence map›Paper›PMID 33758800›Full record

ArticleJAMIA open2021

Natural language processing and machine learning of electronic health records for prediction of first-time suicide attempts.

Fuchiang R Tsui, Lingyun Shi, Victor Ruiz, Neal D Ryan, Candice Biernesser, Satish Iyengar, Colin G Walsh, David A Brent

Registry-linked trialAbstract read
In one paragraph

Article in JAMIA open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06341634 (Surveillance of Suicide Ideation in Adolescents), which is not on this map. Cited by 71 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06341634 enrolling by invitationnot on this mapstarted 2024, after this paper: background citation

Surveillance of Suicide Ideation in Adolescents (VISIA)

TypeobservationalSponsorServicio Gallego de SaludRan2024 to 2025Enrolled339ConditionsSuicide, Distress, Emotional, Adolescent Behavior, Healthy
3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  13. Characterisation of serious mental illness trajectories through transdiagnostic clinical features.The British journal of psychiatry : the journal of mental science · 2026
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  15. Life events extraction from healthcare notes for veteran acute suicide risk prediction.Journal of the American Medical Informatics Association : JAMIA · 2026
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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fuchiang R TsuiTsui Laboratory, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-6383-8471
Lingyun ShiTsui Laboratory, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Victor RuizTsui Laboratory, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Neal D RyanDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Candice BiernesserDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Satish IyengarDepartment of Statistics, School of Arts and Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Colin G WalshDepartment of Biomedical Informatics, School of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
David A BrentDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

The Center for Enhancing Triage and Utilization for Depression and Emergent Suicidality (ETUDES) in Pediatric Primary CareP50MH115838 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRUCE Lawrence ROLLMAN · 2018 to 2026
$25.5M
NIMH NIH HHS P50 MH115838
6 · The paper itself

Abstract

objectiveLimited research exists in predicting first-time suicide attempts that account for two-thirds of suicide decedents. We aimed to predict first-time suicide attempts using a large data-driven approach that applies natural language processing (NLP) and machine learning (ML) to unstructured (narrative) clinical notes and structured electronic health record (EHR) data.

methodsThis case-control study included patients aged 10-75 years who were seen between 2007 and 2016 from emergency departments and inpatient units. Cases were first-time suicide attempts from coded diagnosis; controls were randomly selected without suicide attempts regardless of demographics, following a ratio of nine controls per case. Four data-driven ML models were evaluated using 2-year historical EHR data prior to suicide attempt or control index visits, with prediction windows from 7 to 730 days. Patients without any historical notes were excluded. Model evaluation on accuracy and robustness was performed on a blind dataset (30% cohort).

resultsThe study cohort included 45 238 patients (5099 cases, 40 139 controls) comprising 54 651 variables from 5.7 million structured records and 798 665 notes. Using both unstructured and structured data resulted in significantly greater accuracy compared to structured data alone (area-under-the-curve [AUC]: 0.932 vs. 0.901

conclusionsOur large data-driven approach using both structured and unstructured EHR data demonstrated accurate and robust first-time suicide attempt prediction, and has the potential to be deployed across various populations and clinical settings.

Indexed as

electronic health recordsmachine learningnatural language processingsuicide attempt

Identifiers

PMID33758800
PMCPMC7966858

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.