ArticleClinical psychological science : a journal of the Association for Psychological Science2020
The Disruptive Effects of Estrogen Removal before Puberty on Risk for Binge Eating in Female Rats.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Gondal hormones and binge eating in females: developmental and etiologic insights from puberty to adulthood.Current opinion in psychiatry · 2025Review
- Review
- Estrogen moderation of genetic influences on eating disorder symptoms during gonadarche in girls: Specific effects on binge eating.Psychoneuroendocrinology · 2023Article
- The organizational role of ovarian hormones during puberty on risk for binge-like eating in rats.Physiology & behavior · 2023Review
- Exploring the possibility of parents' broad internalizing phenotype acting through passive gene-environment correlations on daughters' disordered eating.Development and psychopathology · 2022Article
- Editorial: The critical need to assess pubertal development in studies of child and adolescent psychopathology.Journal of child psychology and psychiatry, and allied disciplines · 2022Article
- A comparative study of orthorexia between premenopausal, perimenopausal, and postmenopausal women.Eating and weight disorders : EWD · 2022Article
- Gonadal Hormone Influences on Sex Differences in Binge Eating Across Development.Current psychiatry reports · 2021Review
- Trait negative affect interacts with ovarian hormones to predict risk for emotional eating.Clinical psychological science : a journal of the Association for Psychological Science · 2021Article
- A Narrative Review of Sex Differences in Eating Disorders: Is There a Biological Basis?Clinical therapeutics · 2021Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Recent research suggests that estrogen is protective against binge eating in adult females, and that pubertal estrogen may be critical for these effects. Nonetheless, to date, no study has examined the role of pubertal estrogen in adult binge eating phenotypes in females, potentially due to difficulties experimentally manipulating estrogen in humans to examine causal effects. We used a novel animal model to examine whether estrogen removal prior to puberty (via pre-pubertal ovariectomy (P-OVX)) increases rates of binge eating prone (BEP) phenotypes in adulthood in females. A total of 77 P-OVX and 79 intact rats were followed from pre-puberty into adulthood and phenotyped for BEP status in adulthood. Results showed significantly increased rates (~2-8x higher) of adult BEP phenotypes in P-OVX as compared to intact rats. Findings confirm that estrogen removal substantially increases later risk for binge eating in females, potentially by disrupting typical adolescent brain development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.