ArticleClinical psychological science : a journal of the Association for Psychological Science2020
Effort, avolition and motivational experience in schizophrenia: Analysis of behavioral and neuroimaging data with relationships to daily motivational experience.
Article in Clinical psychological science : a journal of the Association for Psychological Science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Neuroscience meets behavior: A systematic literature review on magnetic resonance imaging of the brain combined with real-world digital phenotyping.Human brain mapping · 2024Pooled it
- Effort-Cost Decision-making Among Individuals With Schizophrenia: A Systematic Review and Meta-analysis.JAMA psychiatry · 2023Pooled it
- Efficacy and Safety of Roluperidone for the Treatment of Negative Symptoms of Schizophrenia.Schizophrenia bulletin · 2022Trial
- MIDnight for the Monetary Incentive Delay Task as an Endophenotype?Biological psychiatry global open science · 2026Article
- Effects of chemotherapy on cognitive and physical effort-based decision-making tasks in rats.Psychopharmacology · 2026Article
- Multimodal EEG-MRI Neuroimaging in Schizophrenia-A Systematic and Mechanistic Review.Journal of clinical medicine · 2026Review
- Computational phenotypes underlying effort-based decision-making and negative symptoms in a transdiagnostic severe mental illness sample.Molecular psychiatry · 2026Article
- Negative symptoms and resting state functional connectivity: Leveraging ecological momentary assessment and individual-specific techniques.Schizophrenia research · 2026Article
- Shared and distinct features of common effort-based decision-making paradigms and their relation to brain structure and neuropsychiatric conditions: An integrated narrative review.Cognitive, affective & behavioral neuroscience · 2026Review
- AI-enabled passive digital phenotyping of experiential negative symptoms in schizophrenia-spectrum disorders: a narrative review on the path from sensing to clinical endpoints.Frontiers in psychiatry · 2026Review
- Anhedonia in Depressive Disorder and Schizophrenia: An Overview of Causes, Diagnosis, and Treatment.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Passive sensing of anhedonia and amotivation in a transdiagnostic sample.Journal of psychopathology and clinical science · 2025Article
- Probabalistic reinforcement learning impairments predict negative symptom severity and risk for conversion in youth at clinical high-risk for psychosis.Psychological medicine · 2025Article
- Abnormal hedonic process in patients with stable schizophrenia: Relationships to negative symptoms and social functioning.Schizophrenia research. Cognition · 2024Article
- Neurobiological foundations and clinical relevance of effort-based decision-making.Brain imaging and behavior · 2024Review
- Pharmacological characterization of sex differences in the effects of dopaminergic drugs on effort-based decision making in rats.Psychopharmacology · 2024Article
- Generalized Encoding of the Relative Subjective Value of Cognitive Effort in the Dorsal ACC.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dampened motivation in schizophrenia: evidence from a novel effort-based decision-making task in social scenarios.European archives of psychiatry and clinical neuroscience · 2024Article
- A Transdiagnostic Study of Effort-Cost Decision-Making in Psychotic and Mood Disorders.Schizophrenia bulletin · 2024Article
- Rationale and Challenges for a New Instrument for Remote Measurement of Negative Symptoms.Schizophrenia bulletin open · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent research suggests that schizophrenia is associated with reduced effort allocation. We examined willingness to expend effort, neural correlates of effort allocation, and the relationship of effort to daily motivational experience in schizophrenia. We recruited 28 individuals with schizophrenia and 30 controls to perform an effort task during fMRI. Individuals with schizophrenia also completed an ecological momentary assessment (EMA) protocol. Individuals with schizophrenia with high negative symptoms were less willing to expend effort for rewards. Daily EMA assessments of motivation were positively associated with effort allocation at a trend-level. Individuals with schizophrenia and controls displayed similar increases in BOLD activation in frontal, cingulate, parietal, and insular regions during effort-based decision-making. However, negative symptoms were associated with reduced BOLD activation in bilateral ventral striatum. These results replicate previous reports of reduced effort allocation in schizophrenia patients with severe negative symptoms, and provide evidence for the role of ventral striatum in effort impairments.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.