ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2021
Associations of Metabolic/Obesity Phenotypes with Insulin Resistance and C-Reactive Protein: Results from the CNTR Study.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 14 citations in OpenAlex.
- Insights into Metabolically Healthy Obesity-A Narrative Review.Journal of clinical medicine · 2026Review
- Review
- Diabetes Mellitus Duration and Major Adverse Cardiovascular Events Following Percutaneous Coronary Intervention: A Prospective Cohort Study.International journal of vascular medicine · 2026Article
- Association between waist-to-height ratio and cardiovascular events in patients with chronic obstructive pulmonary disease: the mediating effect of prognostic nutritional index.BMC cardiovascular disorders · 2025Article
- The triglycerides and glucose index is more strongly associated with metabolically healthy obesity phenotype than the lipid and obesity indices.Journal of endocrinological investigation · 2024Article
- Triglyceride-glucose index as a mediator of body mass index and cardiovascular disease in middle-aged and older Chinese adults: a nationally representative longitudinal cohort study.Frontiers in endocrinology · 2024Article
- Shared and Distinct Gut Microbial Profiles in Saudi Women with Metabolically Healthy and Unhealthy Obesity.Microorganisms · 2023Article
- Diet-Related Inflammation Is Associated with Worse COVID-19 Outcomes in the UK Biobank Cohort.Nutrients · 2023Article
- Insulin resistance mediates obesity-related risk of cardiovascular disease: a prospective cohort study.Cardiovascular diabetology · 2022Article
- Obesity phenotypes related to musculoskeletal disorders; a cross-sectional study from RaNCD cohort.Archives of public health = Archives belges de sante publique · 2022Article
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11 authors at 5 institutions in 1 country.
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Abstract
backgroundObesity is a heterogeneous condition in terms of metabolic status. Different obesity phenotypes have various health risks. The aim of this work was to define different subtypes of obesity and investigate their relationship with inflammatory-cardiometabolic abnormalities among Chinese adult twins.
methodsThe analyses used data from 1113 adult twins in 4 provinces (Shandong, Zhejiang, Jiangsu and Sichuan) from Chinese National Twin Registry (CNTR) which collected detailed information. We defined those with 0 or 1 metabolic syndrome (MetS) components excluding waist circumference as metabolically healthy, and those with waist circumference ≥90 cm (for men) and ≥85 cm (for women) as obese. The two-category obesity status and metabolic states are combined to generate four metabolic/obesity phenotypes. High sensitivity C reactive protein (hsCRP) was measured to assess underlying inflammation and homeostasis model assessment of insulin resistance (HOMA-IR) was calculated as surrogate measure of insulin resistance. Mixed-effect linear regression models and fixed-effect linear regression models were used to analyse the correlation between HOMA-IR, hsCRP and different metabolic/obesity phenotypes.
resultsIn cross-sectional analyses of 1113 individuals (mean [SD] age, 46.6 [12.9] years; 463 obese [41.6%]), 20.3% obese twins were metabolic healthy and 64.2% non-obese twins were metabolic unhealthy. Serum HOMA-IR level was higher in metabolically unhealthy non-obesity (MUNO) (β=0.42, 95% CI: 0.21-0.64), metabolically healthy obesity (MHO) (β=0.68, 95% CI: 0.36-1.00) and metabolically unhealthy obesity (MUO) (β=0.69, 95% CI: 0.46-0.91) twins, compared with their metabolically healthy non-obesity (MHNO) counterparts. HsCRP was similar between MHO and MUO, which differed significantly to metabolic healthy non-obesity (MHNO).
conclusionMHO and MUNO phenotypes were common in Chinese twin population. Both phenotypes were associated with elevated IR and hsCRP which may not be benign and need to be concerned.
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