Trial reportJournal of perinatology : official journal of the California Perinatal Association2021
Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial.
Open access · greenAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 3 citations in OpenAlex.
- Methionine induced placental angiogenesis through activating WNT3A/CTNNB1-PIGF-VEGFR1 pathway.Cell communication and signaling : CCS · 2025Article
- Improving neurodevelopmental trajectories after retinopathy of prematurity: challenges and opportunities.Pediatric research · 2023Article
- Early neurodevelopmental follow-up in the NICHD neonatal research network: Advancing neonatal care and outcomes, opportunities for the future.Seminars in perinatology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors at 20 institutions in 2 countries.
Ira Adams-ChapmanDepartment of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Kristi L WatterbergUniversity of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Tracy L NolenSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina, NC, USA.
Shawn HirschSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina, NC, USA.
Carol A ColeUniversity of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
C Michael CottenDepartment of Pediatrics, Duke University, Durham, NC, USA.
William OhDepartment of Pediatrics, Women & Infants' Hospital, Brown University, Providence, RI, USA.
Brenda B PoindexterDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Kristin M Zaterka-BaxterSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle Park, North Carolina, NC, USA.
Abhik DasSocial, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA.
Conra Backstrom LacyUniversity of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Ann Marie ScorsoneUniversity of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Andrea F DuncanDepartment of Pediatrics, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Sara B DeMauroDepartment of Pediatrics, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA, USA.
Ricki F GoldsteinDepartment of Pediatrics, Duke University, Durham, NC, USA.
Tarah T ColaizyDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.
Deanne E Wilson-CostelloDepartment of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
Isabell B PurdyDepartment of Pediatrics, University of California, Los Angeles, CA, USA.
Susan R HintzDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0001-7023-4433
Roy J HeyneDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Gary J MyersUniversity of Rochester School of Medicine and Dentistry, Rochester, NY, USA.ORCID http://orcid.org/0000-0003-4317-015X
Janell FullerUniversity of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Stephanie MerharDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Heidi M HarmonDepartment of Pediatrics, University of Iowa, Iowa City, IA, USA.ORCID http://orcid.org/0000-0003-2413-1278
Myriam Peralta-CarcelenDivision of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Howard W KilbrideDepartment of Pediatrics, Children's Mercy Hospital and University of Missouri Kansas City School of Medicine, Kansas City, MO, USA.
Nathalie L MaitreDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-8520-9302
Betty R VohrDepartment of Pediatrics, Women & Infants' Hospital, Brown University, Providence, RI, USA.
Girija NatarajanDepartment of Pediatrics, Wayne State University, Detroit, MI, USA.
Helen Mintz-HittnerDepartment of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, USA.
Graham E QuinnDepartment of Ophthalmology, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9006-3464
David K WallaceDepartment of Ophthalmology, Duke University, Durham, NC, USA.
Richard J OlsonDepartment of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA.
Faruk H OrgeDepartment of Ophthalmology, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
Irena TsuiDepartment of Ophthalmology, University of California, Los Angeles, CA, USA.
Michael GaynonDepartment of Ophthalmology, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
Amy K HutchinsonDepartment of Ophthalmology, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
Yu-Guang HeDepartment of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Timothy W WinterDivision of Ophthalmology/Department of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Michael B YangDepartment of Ophthalmology, Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Kathryn M HaiderDepartment of Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA.
Martin S CogenDepartment of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA.
Denise HugDepartment of Ophthalmology, Children's Mercy Hospital and University of Missouri Kansas City School of Medicine, Kansas City, MO, USA.
Don L BremerDepartment of Ophthalmology, Nationwide Children's Hospital, Columbus, OH, USA.
John P DonahueAlpert Medical School of Brown University and Consulting Staff, Women & Infants Hospital of Rhode Island, Providence, RI, USA.
William R LucasDepartment of Ophthalmology, Wayne State University, Detroit, MI, USA.
Dale L PhelpsUniversity of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Rosemary D HigginsEunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. rhiggin@gmu.edu.ORCID http://orcid.org/0000-0001-5590-9826
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Memorial Hermann · USWomen & Children's Hospital of Buffalo · USChildren's Hospital of Philadelphia · USParkland Health & Hospital System · USUniversity of Iowa · USLucile Packard Children's Hospital · USNationwide Children's Hospital · USRTI International · USHutzel Women's Hospital · USUniversity of New Mexico · USChildren's of Alabama · USRiley Hospital for Children · USCincinnati Children's Hospital Medical Center · USDuke University · USMattel Children's Hospital · USUniversity of Rochester · USBrown University · USChildren's Mercy Hospital · USEmory University · USNational Institutes of Health · US
Funding
Neonatal Research Network Data Coordinating Center (DCC) 2023-2028U24HD095254 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI Abhik Das · 2018 to 2026
$70.2MNeonatal Research Network Data Coordinating Center (DCC)U10HD036790 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI DAS, ABHIK · 2008 to 2017
$62.3MConvalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3MStanford Center for Clinical & Translational Education and Research (Spectrum)UL1TR003142 · NCATS · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2019 to 2023
$45.0MDuke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3MAtlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8MThe University of Rochester's Clinical and Translational Science InstituteUL1TR000042 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$14.4MUniversity of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0MCincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E. · 2012 to 2014
$9.9MUniversity of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8MStanford Center for Clinical and Translational Education and Research (SCCTER)UL1UL1TR000093 · NCATS · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2012 to 2013
$6.5MInstitutional Career Development CoreKL2TR003168 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MILLER, CHARLES C · 2019 to 2023
$4.9MNCATS NIH HHS KL2 TR003168NCATS NIH HHS UL1 TR000041NCATS NIH HHS UL1 TR000042NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR000093NCATS NIH HHS UL1 TR000442NCATS NIH HHS UL1 TR000454NCATS NIH HHS UL1 TR001117NCATS NIH HHS UL1 TR003142NCATS NIH HHS UL1 TR003167NICHD NIH HHS U10 HD036790NICHD NIH HHS U24 HD095254NICHD NIH HHS UG1 HD021364NICHD NIH HHS UG1 HD021385NICHD NIH HHS UG1 HD027851NICHD NIH HHS UG1 HD027853NICHD NIH HHS UG1 HD027856NICHD NIH HHS UG1 HD027880NICHD NIH HHS UG1 HD027904NICHD NIH HHS UG1 HD034216NICHD NIH HHS UG1 HD040492NICHD NIH HHS UG1 HD040689NICHD NIH HHS UG1 HD053089NICHD NIH HHS UG1 HD053109NICHD NIH HHS UG1 HD068244NICHD NIH HHS UG1 HD068263NICHD NIH HHS UG1 HD068270NICHD NIH HHS UG1 HD068278NICHD NIH HHS UG1 HD068284NICHD NIH HHS UG1 HD087226NICHD NIH HHS UG1 HD087229U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) U10 HD36790U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD21385U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD27851U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD27853U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD27880U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD27904U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD34216U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD40492U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD40689U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD53089U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD68244U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD68263U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) UG1 HD68284U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1 TR1117U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1 TR41U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1 TR42U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1 TR454U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1 TR77U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1 TR93U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL! TR1117
Abstract
objectiveThis study evaluates the 24-month follow-up for the NICHD Neonatal Research Network (NRN) Inositol for Retinopathy Trial. STUDY
designBayley Scales of Infants Development-III and a standardized neurosensory examination were performed in infants enrolled in the main trial. Moderate/severe NDI was defined as BSID-III Cognitive or Motor composite score <85, moderate or severe cerebral palsy, blindness, or hearing loss that prevents communication despite amplification were assessed.
resultsPrimary outcome was determined for 605/638 (95%). The mean gestational age was 25.8 ± 1.3 weeks and mean birthweight was 805 ± 192 g. Treatment group did not affect the risk for the composite outcome of death or survival with moderate/severe NDI (60% vs 56%, p = 0.40).
conclusionsTreatment group did not affect the risk of death or survival with moderate/severe NDI. Despite early termination, this study represents the largest RCT of extremely preterm infants treated with myo-inositol with neurodevelopmental outcome data.
Indexed as
Cerebral PalsyInfant, Extremely PrematureChild DevelopmentGestational AgeHumansInfant, NewbornInositolInositol
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.