Evidence map›Paper›PMID 33758372›Full record

ArticleThe Journal of antibiotics2021

Saccharobipyrimicin, a new antibiotic from the leaf-litter actinomycete Saccharothrix sp. MM696L-181F4.

Yasuhiro Takehana, Hideyuki Muramatsu, Maya Umekita, Chigusa Hayashi, Tomoyuki Kimura, Ryuichi Sawa, Masayuki Igarashi

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. AI-Assisted Isolation of Bioactive Dipyrimicins fromJournal of natural products · 2026
    Article
  2. AI-assisted isolation of bioactive Dipyrimicins frombioRxiv : the preprint server for biology · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yasuhiro TakehanaInstitute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Tokyo, Japan. takehanay@bikaken.or.jp.
Hideyuki MuramatsuInstitute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Tokyo, Japan.
Maya UmekitaInstitute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Tokyo, Japan.
Chigusa HayashiInstitute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Tokyo, Japan.
Tomoyuki KimuraInstitute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Tokyo, Japan.
Ryuichi SawaInstitute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Tokyo, Japan.
Masayuki IgarashiInstitute of Microbial Chemistry (BIKAKEN), Shinagawa-ku, Tokyo, Japan. igarashim@bikaken.or.jp.ORCID 0000-0002-1562-6685

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the course of screening for new antimicrobial compounds, a new antibiotic substance named saccharobipyrimicin was isolated from the leaf-litter actinomycete Saccharothrix sp. MM696L-181F4. The structure of saccharobipyrimicin was elucidated by various spectral methods, mainly single-crystal X-ray analysis and chemical degradation. It revealed that saccharobipyrimicin contained a 2,2'-bipyridine skeletal structure. Saccharobipyrimicin showed moderate and broad-spectrum antimicrobial activity. Two chemical derivatives of saccharobipyrimicin showed weaker antimicrobial activities than that of saccharobipyrimicin against most test microorganisms except two tolC mutants of Escherichia coli and Neisseria gonorrhoeae.

Indexed as

ActinomycetalesAnti-Bacterial AgentsEscherichia coliMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMolecular StructureNeisseria gonorrhoeaePlant LeavesSpectrometry, Mass, Electrospray IonizationAnti-Bacterial Agents

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.