ArticleScientific reports2021
Osteoinductive 3D printed scaffold healed 5 cm segmental bone defects in the ovine metatarsus.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Instrumentalized 3D printed scaffolds enable bone regeneration and fracture healing monitoring in critical size bone defects.APL bioengineering · 2026Article
- 3D-Printed Bone Spacers with Dual-Phase Structure: A Comparison of Biogenic and Commercial Hydroxyapatite for Potential Treatment of Bone Defects.ACS applied bio materials · 2026Article
- "Anti-Bios": Can Local Antibiotics Affect Bone Union in Infected Bone Defects Treated with Degradable Bone Substitutes.Biomedicines · 2025Article
- Natural medicine delivery from 3D printed bone substitutes.Journal of controlled release : official journal of the Controlled Release Society · 2024Review
- Modular design workflow for 3D printable bioresorbable patient-specific bone scaffolds: extended features and clinical validation.Frontiers in bioengineering and biotechnology · 2024Article
- 3D-Printed Osteoinductive Polymeric Scaffolds with Optimized Architecture to Repair a Sheep Metatarsal Critical-Size Bone Defect.Advanced healthcare materials · 2023Article
- Employing direct electromagnetic coupling to assess acute fracture healing: An ovine model assessment.Injury · 2023Article
- An osteoinductive and biodegradable intramedullary implant accelerates bone healing and mitigates complications of bone transport in male rats.Nature communications · 2023Article
- Robocasting of Ceramic Fischer-Koch S Scaffolds for Bone Tissue Engineering.Journal of functional biomaterials · 2023Article
- Evaluation of a Bioabsorbable Scaffold and Interlocked Nail System for Segmental Bone Defect.Journal of functional biomaterials · 2023Article
- Mechanical comparison of application of locking intramedullary nail to locking compression plate in the ovine metatarsus.Annals of translational medicine · 2023Article
- Scaffold Guided Bone Regeneration for the Treatment of Large Segmental Defects in Long Bones.Biomedicines · 2023Review
- Sterilization of Polymeric Implants: Challenges and Opportunities.ACS applied bio materials · 2022Review
- Engineering Extracellular Microenvironment for Tissue Regeneration.Bioengineering (Basel, Switzerland) · 2022Review
- Probing the role of methyl methacrylate release from spacer materials in induced membrane bone healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Polycaprolactone/Gelatin/Hydroxyapatite Electrospun Nanomembrane Materials Incorporated with Different Proportions of Attapulgite Synergistically Promote Bone Formation.International journal of nanomedicine · 2022Article
- Regeneration of Bone Defects in a Rabbit Femoral Osteonecrosis Model Using 3D-Printed Poly (Epsilon-Caprolactone)/Nanoparticulate Willemite Composite Scaffolds.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
Abstract
Autologous bone grafts are considered the gold standard grafting material for the treatment of nonunion, but in very large bone defects, traditional autograft alone is insufficient to induce repair. Recombinant human bone morphogenetic protein 2 (rhBMP-2) can stimulate bone regeneration and enhance the healing efficacy of bone grafts. The delivery of rhBMP-2 may even enable engineered synthetic scaffolds to be used in place of autologous bone grafts for the treatment of critical size defects, eliminating risks associated with autologous tissue harvest. We here demonstrate that an osteoinductive scaffold, fabricated by combining a 3D printed rigid polymer/ceramic composite scaffold with an rhBMP-2-eluting collagen sponge can treat extremely large-scale segmental defects in a pilot feasibility study using a new sheep metatarsus fracture model stabilized with an intramedullary nail. Bone regeneration after 24 weeks was evaluated by micro-computed tomography, mechanical testing, and histological characterization. Load-bearing cortical bridging was achieved in all animals, with increased bone volume observed in sheep that received osteoinductive scaffolds compared to sheep that received an rhBMP-2-eluting collagen sponge alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.