ArticleScientific reports2021
On the impact of vessel wall stiffness on quantitative flow dynamics in a synthetic model of the thoracic aorta.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Embolic Transport in LVAD Outflow: An Experimental Study Using Patient-Specific and Idealized Aortic Models.Annals of biomedical engineering · 2026Article
- MRI-Based Pressure Gradient Mapping in Patient-Specific Models of Coarctation of the Aorta.medRxiv : the preprint server for health sciences · 2026Article
- An Experimental Measurement Method to Characterize and Apply Platinum Silicon Material for a Biomechanical Replica of the Thoracic Aorta.Biomimetics (Basel, Switzerland) · 2026Article
- Development and Characteristics of a Dual-Layered Vascular Phantom.Cardiovascular engineering and technology · 2026Article
- The Current State of Mock Circulatory Loop Applications in Aortic and Cardiovascular Research: A Scoping Review.Biomedicines · 2025Review
- 3D-printed in vitro models of Stanford type B aortic dissection: A scoping review.Journal of vascular surgery cases and innovative techniques · 2025Article
- Impact of Residual Intimal Flap Displacement Post-TEVAR on TBAD Haemodynamics in Compliant, Patient-specific CFD Simulations Informed by MRI.Annals of biomedical engineering · 2025Article
- Experiments and Simulations to Assess Exercise-Induced Pressure Drop Across Aortic Coarctations.Journal of biomechanical engineering · 2025Article
- Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- A hybrid mock circulatory loop integrated with a LED-PIV system for the investigation of AAA compliant phantoms.Frontiers in bioengineering and biotechnology · 2024Article
- Development of idealized human aortic models forFrontiers in cardiovascular medicine · 2024Article
- Hemodynamic effects of entry and exit tear size in aortic dissection evaluated with in vitro magnetic resonance imaging and fluid-structure interaction simulation.Scientific reports · 2023Article
- Validating MRI-Derived Myocardial Stiffness Estimates Using In Vitro Synthetic Heart Models.Annals of biomedical engineering · 2023Article
- Validation of the Reduced Unified Continuum Formulation Against In Vitro 4D-Flow MRI.Annals of biomedical engineering · 2023Article
- Fabrication of deformable patient-specific AAA models by material casting techniques.Frontiers in cardiovascular medicine · 2023Article
- Mechanical testing and comparison of porcine tissue, silicones and 3D-printed materials for cardiovascular phantoms.Frontiers in bioengineering and biotechnology · 2023Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Aortic wall stiffening is a predictive marker for morbidity in hypertensive patients. Arterial pulse wave velocity (PWV) correlates with the level of stiffness and can be derived using non-invasive 4D-flow magnetic resonance imaging (MRI). The objectives of this study were twofold: to develop subject-specific thoracic aorta models embedded into an MRI-compatible flow circuit operating under controlled physiological conditions; and to evaluate how a range of aortic wall stiffness impacts 4D-flow-based quantification of hemodynamics, particularly PWV. Three aorta models were 3D-printed using a novel photopolymer material at two compliant and one nearly rigid stiffnesses and characterized via tensile testing. Luminal pressure and 4D-flow MRI data were acquired for each model and cross-sectional net flow, peak velocities, and PWV were measured. In addition, the confounding effect of temporal resolution on all metrics was evaluated. Stiffer models resulted in increased systolic pressures (112, 116, and 133 mmHg), variations in velocity patterns, and increased peak velocities, peak flow rate, and PWV (5.8-7.3 m/s). Lower temporal resolution (20 ms down to 62.5 ms per image frame) impacted estimates of peak velocity and PWV (7.31 down to 4.77 m/s). Using compliant aorta models is essential to produce realistic flow dynamics and conditions that recapitulated in vivo hemodynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.