Evidence map›Paper›PMID 33758260›Full record

SynthesisScientific reports2021

A meta-analysis on heart rate variability biofeedback and depressive symptoms.

Silvia F M Pizzoli, Chiara Marzorati, Daniele Gatti, Dario Monzani, Ketti Mazzocco, Gabriella Pravettoni

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06821035 (Teaching Youth & Families Self-Regulation Skills to Disrupt the Impact of Adverse Childhood Experiences), which is not on this map. Cited by 79 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 7 pooled it
17.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06821035 narecruitingnot on this mapstarted 2025, after this paper: background citation

Teaching Youth & Families Self-Regulation Skills to Disrupt the Impact of Adverse Childhood Experiences: Preventing Substance Use in Adversity- Impacted Youth

TypeinterventionalSponsorUniversity of California, IrvineRan2025 to 2028Enrolled210ConditionsAdverse Childhood Experiences, Family FunctioningArmsGarnering Resilience in Traumatized youth and families (GRIT), Digital Citizenship Curriculum (DCC)
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 7 syntheses or guidelines pooled it, 157 citations in OpenAlex.

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  11. Addressing Mental Health Symptoms Among COVID-19 Healthcare Workers: A Heart Rate Variability Biofeedback Pilot Study.Stress and health : journal of the International Society for the Investigation of Stress · 2024
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  14. Daily heart rate variability biofeedback training decreases locus coeruleus MRI contrast in younger adults in a randomized clinical trial.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2023
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Silvia F M PizzoliDepartment of Oncology and Hemato-Oncology, University of Milan, Via Festa del Perdono 7, 20122, Milan, Italy. silviafrancescamaria.pizzoli@ieo.it.
Chiara MarzoratiApplied Research Division for Cognitive and Psychological Science, European Institute of Oncology IEO, IRCCS, Milan, Italy.
Daniele GattiDepartment of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Dario MonzaniDepartment of Oncology and Hemato-Oncology, University of Milan, Via Festa del Perdono 7, 20122, Milan, Italy.
Ketti MazzoccoDepartment of Oncology and Hemato-Oncology, University of Milan, Via Festa del Perdono 7, 20122, Milan, Italy.
Gabriella PravettoniDepartment of Oncology and Hemato-Oncology, University of Milan, Via Festa del Perdono 7, 20122, Milan, Italy.
University of Milan · ITEuropean Institute of Oncology · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart rate variability biofeedback (HRVB) has been used for a number of years to treat depressive symptoms, a common mental health issue, which is often comorbid with other psychopathological and medical conditions. The aim of the present meta-analysis is to test whether and to what extent HRVB is effective in reducing depressive symptoms in adult patients. We conducted a literature search on Pubmed, ProQuest, Ovid PsycInfo, and Embase up to October 2020, and identified 721 studies. Fourteen studies were included in the meta-analysis. Three meta-regressions were also performed to further test whether publication year, the questionnaire used to assess depressive symptoms, or the interval of time between T0 and T1 moderated the effect of HRVB. Overall, we analysed 14 RCTs with a total of 794 participants. The random effect analysis yielded a medium mean effect size g = 0.38 [95% CI = 0.16, 0.60; 95% PI =  - 0.19, 0.96], z = 3.44, p = 0.0006. The total heterogeneity was significant, Q

Indexed as

Biofeedback, PsychologyHeart RatePsychotherapyDepressionDisease ManagementDisease SusceptibilityHumansOutcome Assessment, Health CarePublication BiasSymptom Assessment

Identifiers

PMID33758260
PMCPMC7988005
OpenAlexW3138204312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.