Evidence map›Paper›PMID 33758225›Full record

ArticleScientific reports2021

PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons.

Sarah J Brown, Ibrahim Boussaad, Javier Jarazo, Julia C Fitzgerald, Paul Antony, Marcus Keatinge, Janna Blechman, Jens C Schwamborn, Rejko Krüger, Marysia Placzek and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  4. Article
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  6. Frontiers in aging neuroscience · 2026
    Review
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  9. Long-term exposure to PMScientific reports · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 5 countries.

Sarah J Brown *Bateson Centre, University of Sheffield, Sheffield, UK.
Ibrahim Boussaad *Translational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.ORCID 0000-0002-3512-3364
Javier Jarazo *Developmental Biology, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.
Julia C FitzgeraldHertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.
Paul AntonyTranslational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.ORCID 0000-0002-0450-9301
Marcus KeatingeBateson Centre, University of Sheffield, Sheffield, UK.
Janna BlechmanWeizmann Institute of Science, Rehovot, Israel.
Jens C SchwambornDevelopmental Biology, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.ORCID 0000-0003-4496-0559
Rejko KrügerTranslational Neuroscience, Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.
Marysia Placzek *Bateson Centre, University of Sheffield, Sheffield, UK.
Oliver Bandmann *Bateson Centre, University of Sheffield, Sheffield, UK. o.bandmann@sheffield.ac.uk.
University of Luxembourg · LUUniversity of Sheffield · GBCentre Hospitalier de Luxembourg · LUDiscovery Centre · CAHertie Institute for Clinical Brain Research · DEWeizmann Institute of Science · IL

Funding

Medical Research Council G0400100Medical Research Council G0401310Medical Research Council G0700091Medical Research Council G0801680Medical Research Council G0802527Medical Research Council GO802527Medical Research Council MR/R011354/1Medical Research Council R011354/1Wellcome Trust 212247/Z/18/Z
6 · The paper itself

Abstract

Recent evidence suggests neurogenesis is on-going throughout life but the relevance of these findings for neurodegenerative disorders such as Parkinson's disease (PD) is poorly understood. Biallelic PINK1 mutations cause early onset, Mendelian inherited PD. We studied the effect of PINK1 deficiency on adult neurogenesis of dopaminergic (DA) neurons in two complementary model systems. Zebrafish are a widely-used model to study neurogenesis in development and through adulthood. Using EdU analyses and lineage-tracing studies, we first demonstrate that a subset of ascending DA neurons and adjacent local-projecting DA neurons are each generated into adulthood in wild type zebrafish at a rate that decreases with age. Pink1-deficiency impedes DA neurogenesis in these populations, most significantly in early adult life. Pink1 already exerts an early effect on Th1

Indexed as

Age FactorsAnimalsAnimals, Genetically ModifiedBiomarkersCell DifferentiationDisease Models, AnimalDopaminergic NeuronsFluorescent Antibody TechniqueHumansMesencephalonNeurogenesisParkinson DiseaseProtein Serine-Threonine KinasesPTEN-Induced Putative KinaseZebrafishZebrafish ProteinsBiomarkersPink1 protein, zebrafishProtein Serine-Threonine KinasesPTEN-Induced Putative KinaseZebrafish Proteins

Identifiers

PMID33758225
PMCPMC7988014
OpenAlexW3136968663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.