Evidence map›Paper›PMID 33758101›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

miRNA-independent function of long noncoding pri-miRNA loci.

Daniel He, David Wu, Soren Muller, Lin Wang, Parna Saha, Sajad Hamid Ahanger, Siyuan John Liu, Miao Cui, Sung Jun Hong, Miten Jain and 5 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. TheProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. A long noncoding RNA at theProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Review
  10. Review
  11. Article
  12. Deciphering the Functional Long Non-Coding RNAs Derived from MicroRNA Loci.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Daniel HeDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.
David WuDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.
Soren MullerDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.
Lin WangDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.
Parna SahaDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.ORCID 0000-0001-9219-5017
Sajad Hamid AhangerDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.ORCID 0000-0002-9531-6221
Siyuan John LiuDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.ORCID 0000-0003-1042-0191
Miao CuiDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.ORCID 0000-0001-7751-9159
Sung Jun HongDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.
Miten JainDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA 95064.ORCID 0000-0002-4571-3982
Hugh E OlsonDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA 95064.
Mark AkesonDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA 95064.ORCID 0000-0001-9392-8075
Joseph F CostelloDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.ORCID 0000-0003-3189-584X
Aaron DiazDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143.
Daniel A LimDepartment of Neurological Surgery, Biomedical Sciences Graduate Program, University of California, San Francisco, CA 94143; daniel.lim@ucsf.edu.ORCID 0000-0001-7221-3425
University of California, San Francisco · USSan Francisco VA Medical Center · USUniversity of California, Santa Cruz · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANDERSON, MARK S · 1985 to 2020
$29.6M
PREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7M
Training Program in Translational Brain Tumor ResearchT32CA151022 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2010 to 2026
$6.6M
A Unified Nanopore Platform for Direct Sequencing of Individual Full Length RNA Strands Bearing Modified NucleotidesR01HG010053 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI AKESON, MARK A · 2018 to 2021
$3.8M
Long noncoding RNA regulation of neural stem cellsR01NS091544 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2016 to 2020
$1.7M
Functional long noncoding RNAs in human gliomaR21NS101395 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2017 to 2018
$436k
NCI NIH HHS T32 CA151022NHGRI NIH HHS R01 HG010053NICHD NIH HHS T32 HD007470NIGMS NIH HHS T32 GM007618NINDS NIH HHS R01 NS091544NINDS NIH HHS R21 NS101395
6 · The paper itself

Abstract

Among the large, diverse set of mammalian long noncoding RNAs (lncRNAs), long noncoding primary microRNAs (lnc-pri-miRNAs) are those that host miRNAs. Whether lnc-pri-miRNA loci have important biological function independent of their cognate miRNAs is poorly understood. From a genome-scale lncRNA screen, lnc-pri-miRNA loci were enriched for function in cell proliferation, and in glioblastoma (i.e., GBM) cells with

Indexed as

Genetic LociApoptosisCell ProliferationGene Knockdown TechniquesHEK293 CellsHumansMicroRNAsRNA, Long NoncodingRNA-SeqMicroRNAsMIRN29a microRNA, humanMIRN29B1 microRNA, humanRNA, Long Noncodinghost genelnc-pri-miRNAlncRNAmiRNA

Identifiers

PMID33758101
PMCPMC8020771
OpenAlexW3139393421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.