Evidence map›Paper›PMID 33758093›Full record

ArticlemBio2021

Effect of HIV/HAART and Other Clinical Variables on the Oral Mycobiome Using Multivariate Analyses.

Paul L Fidel, Zach A Thompson, Elizabeth A Lilly, Carolina Granada, Kelly Treas, Kenneth R Dubois, Laura Cook, Shahr B Hashmi, Daniel J Lisko, Chiranjit Mukherjee and 5 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Review
  3. Dysbiosis modulates CD8iScience · 2025
    Article
  4. Article
  5. Salivary mycobiome alterations in HIV-infected MSM: dominance ofFrontiers in cellular and infection microbiology · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Current oral hygiene and recreational behavioral trends in HIV disease.Clinical and experimental dental research · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Paul L FidelCenter of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA pfidel@lsuhsc.edu.ORCID 0000-0001-8066-5763
Zach A ThompsonDivision of Biosciences, The Ohio State University College of Dentistry, Columbus, Ohio, USA.
Elizabeth A LillyCenter of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA.
Carolina GranadaDivision of Infectious Diseases, Department of Medicine, Augusta University, Medical College of Georgia, Augusta, Georgia, USA.
Kelly TreasCenter of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA.
Kenneth R DuboisCenter of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, New Orleans, Louisiana, USA.
Laura CookDivision of Biosciences, The Ohio State University College of Dentistry, Columbus, Ohio, USA.
Shahr B HashmiDivision of Biosciences, The Ohio State University College of Dentistry, Columbus, Ohio, USA.
Daniel J LiskoDivision of Biosciences, The Ohio State University College of Dentistry, Columbus, Ohio, USA.
Chiranjit MukherjeeDivision of Biosciences, The Ohio State University College of Dentistry, Columbus, Ohio, USA.
Jose A VazquezDivision of Infectious Diseases, Department of Medicine, Augusta University, Medical College of Georgia, Augusta, Georgia, USA.
Michael E HagenseeSection of Infectious Disease, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Ann L GriffenDivision of Pediatric Dentistry, The Ohio State University College of Dentistry, Columbus, Ohio, USA.
Eugene J LeysDivision of Biosciences, The Ohio State University College of Dentistry, Columbus, Ohio, USA.
Clifford J BeallDivision of Biosciences, The Ohio State University College of Dentistry, Columbus, Ohio, USA.ORCID 0000-0002-2198-9124
The Ohio State University · USLouisiana State University Health Sciences Center New Orleans · USAugusta University · USUniversity of British Columbia · CA

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI AUGUSTO C. OCHOA · 2012 to 2026
$69.1M
The Oral Microbiome in HIV-associated Oral Warts and CandidiasisR01DE022815 · NIDCR · LSU HEALTH SCIENCES CENTER · PI FIDEL, PAUL L, GRIFFEN, ANN L · 2013 to 2017
$2.8M
NIDCR NIH HHS R01 DE022815NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

The oral microbiome is considered an important factor in health and disease. We recently reported significant effects of HIV and several other clinical variables on the oral bacterial communities in a large cohort of HIV-positive and -negative individuals. The purpose of the present study was to similarly analyze the oral mycobiome in the same cohort. To identify fungi, the internal transcribed spacer 2 (ITS2) of the fungal rRNA genes was sequenced using oral rinse samples from 149 HIV-positive and 88 HIV-negative subjects that had previously undergone bacterial amplicon sequencing. Quantitative PCR was performed for total fungal content and total bacterial content. Interestingly, samples often showed predominance of a single fungal species with four major clusters predominated by

Indexed as

Antiretroviral Therapy, Highly ActiveMultivariate AnalysisBacteriaCohort StudiesDNA, IntergenicFemaleFungiHIVHIV InfectionsHumansMaleMouthMycobiomeDNA, IntergenicCandidaclinical variablesfungal microbiomehuman immunodeficiency virusMalasseziamycobiomeoral microbiome

Identifiers

PMID33758093
PMCPMC8092233
OpenAlexW3137641233

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.