Evidence map›Paper›PMID 33758092›Full record

ArticlemBio2021

Noncanonical Transmission of a Measles Virus Vaccine Strain from Neurons to Astrocytes.

Katrien C K Poelaert, Riley M Williams, Christine M Matullo, Glenn F Rall

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Unraveling the complexities of neurotropic virus infection and immune evasion.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Katrien C K PoelaertFox Chase Cancer Center, Program in Blood Cell Development and Function, Philadelphia, Pennsylvania, USA.
Riley M WilliamsFox Chase Cancer Center, Program in Blood Cell Development and Function, Philadelphia, Pennsylvania, USA.
Christine M MatulloFox Chase Cancer Center, Program in Blood Cell Development and Function, Philadelphia, Pennsylvania, USA.
Glenn F RallFox Chase Cancer Center, Program in Blood Cell Development and Function, Philadelphia, Pennsylvania, USA glenn.rall@fccc.edu.
Fox Chase Cancer Center · USDrexel University · US

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
RNA Virus Persistence and Reactivation in the BrainR21NS099788 · NINDS · RESEARCH INST OF FOX CHASE CAN CTR · PI RALL, GLENN F · 2017 to 2018
$495k
NCI NIH HHS P30 CA006927NINDS NIH HHS R21 NS099788
6 · The paper itself

Abstract

Viruses, including members of the herpes-, entero-, and morbillivirus families, are the most common cause of infectious encephalitis in mammals worldwide. During most instances of acute viral encephalitis, neurons are typically the initial cell type that is infected. However, as replication and spread ensue, other parenchymal cells can become viral targets, especially in chronic infections. Consequently, to ascertain how neurotropic viruses trigger neuropathology, it is crucial to identify which central nervous system (CNS) cell populations are susceptible and permissive throughout the course of infection, and to define how viruses spread between distinct cell types. Using a measles virus (MV) transgenic mouse model that expresses human CD46 (hCD46), the MV vaccine strain receptor, under the control of a neuron-specific enolase promoter (NSE-hCD46

Indexed as

AnimalsAstrocytesCells, CulturedDisease Models, AnimalEncephalitis, ViralFemaleHumansMaleMeasles VaccineMeasles virusMembrane Cofactor ProteinMiceMice, TransgenicNeuronsCD46 protein, humanMeasles VaccineMembrane Cofactor Proteinastrocytemeasles virusneuronneurotransmitter transportersribonucleoproteinsynapse

Identifiers

PMID33758092
PMCPMC8092232
OpenAlexW3136011501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.