Evidence map›Paper›PMID 33758087›Full record

ArticlemBio2021

The Lst Sialyltransferase of Neisseria gonorrhoeae Can Transfer Keto-Deoxyoctanoate as the Terminal Sugar of Lipooligosaccharide: a Glyco-Achilles Heel That Provides a New Strategy for Vaccines to Prevent Gonorrhea.

Freda E-C Jen, Margaret R Ketterer, Evgeny A Semchenko, Christopher J Day, Kate L Seib, Michael A Apicella, Michael P Jennings

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Exploring the Scope of FunctionalizedMolecules (Basel, Switzerland) · 2025
    Article
  2. Article
  3. Article
  4. mBio · 2024
    Article
  5. Clinical microbiology reviews · 2024
    Review
  6. bioRxiv : the preprint server for biology · 2024
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Freda E-C JenGriffith University, Institute for Glycobiology, Gold Coast, Queensland, Australia.
Margaret R KettererDepartment of Microbiology and Immunology and Department of Internal Medicine, The University of Iowa, Iowa City, Iowa, USA.
Evgeny A SemchenkoGriffith University, Institute for Glycobiology, Gold Coast, Queensland, Australia.
Christopher J DayGriffith University, Institute for Glycobiology, Gold Coast, Queensland, Australia.
Kate L SeibGriffith University, Institute for Glycobiology, Gold Coast, Queensland, Australia.ORCID 0000-0002-7094-3528
Michael A ApicellaDepartment of Microbiology and Immunology and Department of Internal Medicine, The University of Iowa, Iowa City, Iowa, USA michael-apicella@uiowa.edu m.jennings@griffith.edu.au.
Michael P JenningsGriffith University, Institute for Glycobiology, Gold Coast, Queensland, Australia michael-apicella@uiowa.edu m.jennings@griffith.edu.au.ORCID 0000-0002-1027-4684
Griffith University · AUUniversity of Iowa · US

Funding

LIPOOLIGOSACCHARIDES OF HAEMOPHILUS INFLUENZAER01AI024616 · NIAID · UNIVERSITY OF IOWA · PI APICELLA, MICHAEL A. · 1988 to 2014
$6.0M
Lysine Acetylation in N. gonorrhoeae Quorum Sensing and Biofilm FormationR01AI108255 · NIAID · UNIVERSITY OF IOWA · PI KIRBY, JOHN R, SCHILLING, BIRGIT · 2014 to 2018
$4.1M
LIPOOLIGOSACCHARIDES OF HAEMOPHILUS INFLUENZAER37AI024616 · NIAID · UNIVERSITY OF IOWA · PI APICELLA, MICHAEL A. · 1994 to 2003
$1.9M
H. influenzae: Role of Sialic Acid in VirulenceR56AI024616 · NIAID · UNIVERSITY OF IOWA · PI APICELLA, MICHAEL A. · 2009 to 2009
$649k
NIAID NIH HHS R01 AI024616NIAID NIH HHS R01 AI108255NIAID NIH HHS R37 AI024616NIAID NIH HHS R56 AI024616
6 · The paper itself

Abstract

The lipooligosaccharide (LOS) of

Indexed as

Antigens, BacterialBacterial Vaccinesbeta-Galactoside alpha-2,3-SialyltransferaseCervix UteriEpithelial CellsFemaleGonorrheaHumansLipopolysaccharidesN-Acetylneuraminic AcidNeisseria gonorrhoeaeNeutrophilsPhagocytosisSialyltransferasesAntigens, BacterialBacterial Vaccinesbeta-Galactoside alpha-2,3-Sialyltransferaselipid-linked oligosaccharidesLipopolysaccharidesN-Acetylneuraminic AcidSialyltransferasesgonococcal vaccineketo-deoxyoctanoate (KDO)lipooligosaccharide (LOS)Lst sialyltransferaseN-acetylneuraminic acid (Neu5Ac)Neisseria gonorrheasialic acid

Identifiers

PMID33758087
PMCPMC8092323
OpenAlexW3138856033

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.