ArticleCancer discovery2021
Obesity-Dependent Adipokine Chemerin Suppresses Fatty Acid Oxidation to Confer Ferroptosis Resistance.
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Article in Cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
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Who cites it
67 citing papers in PubMed, 103 citations in OpenAlex.
- Spatial anchoring of lipid metabolism shapes immune fate in the tumor microenvironment.Lipids in health and disease · 2026Review
- Translating ferroptosis into oncology: challenges, opportunities and future directions.Nature reviews. Clinical oncology · 2026Review
- MAFF regulates ferroptotic sensitivity through iron homeostasis and fatty acid synthesis.Cell death & disease · 2026Article
- OSCAR functions as a collagen I receptor to suppress hippo signaling and reprogram lipid metabolism in clear-cell renal cell carcinoma.Cell death & disease · 2026Article
- Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches.Molecular biomedicine · 2026Review
- Metabolic Messengers: Extracellular Vesicles as Central Mediators of Metabolic Reprogramming in Renal Cell Cancer.Biomedicines · 2026Review
- Ferroptosis in renal cell carcinoma: integrative multi-omics insights and therapeutic perspectives.International journal of surgery (London, England) · 2026Article
- The role of ferroptosis in renal cell carcinoma: molecular mechanisms and therapeutic implications.Journal of molecular medicine (Berlin, Germany) · 2026Review
- Fueling Death: The Metabolic Control of Ferroptosis.Advances in experimental medicine and biology · 2026Review
- Therapeutic targeting SPI1 in combination with erastin promotes ferroptosis in ccRCC.Communications biology · 2025Article
- The adipokines in oral cancer pathogenesis and its potential as a new therapeutic approach.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Chemerin sustains the growth of spongiotrophoblast and sinusoidal trophoblast giant cells through fatty acid oxidation.BMC biology · 2025Article
- Emerging roles for fatty acid oxidation in cancer.Genes & diseases · 2025Review
- Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Regulating obesity-induced osteoarthritis by targeting p53-FOXO3, osteoclast ferroptosis, and mesenchymal stem cell adipogenesis.Nature communications · 2025Article
- ZIP8 modulates ferroptosis to drive esophageal carcinoma progression.Cell death & disease · 2025Article
- LPCAT3 regulates the immune infiltration and prognosis of ccRCC patients by mediating ferroptosis and endoplasmic reticulum stress.Discover oncology · 2025Article
- Active Forms of Chemerin Are Elevated in Human and Mouse Ovarian Carcinoma.Biomedicines · 2025Article
- Multiomic traits reveal that critical irinotecan-related core regulator FSTL3 promotes CRC progression and affects ferroptosis.Cancer cell international · 2025Article
- The Role of Perirenal Adipose Tissue in Carcinogenesis-From Molecular Mechanism to Therapeutic Perspectives.Cancers · 2025Review
7 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 8 institutions in 2 countries.
Sze Kiat TanDepartment of Radiation Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.ORCID 0000-0001-9653-555X
Iqbal MahmudDepartment of Pathology, Immunology and Laboratory Medicine, UF Health, UF Health Cancer Center, Southeast Center for Integrated Metabolomics, Clinical and Translational Science Institute, College of Medicine, University of Florida, Gainesville, Florida.
Flavia FontanesiDepartment of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, Florida.
Michelle PuchowiczDepartment of Pediatrics, Metabolic Phenotyping Core, Pediatric Obesity Program, University of Tennessee Health Science Center, Memphis, Tennessee.
Chase K A NeumannDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Anthony J GriswoldJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, Florida.
Rutulkumar PatelDepartment of Radiation Oncology, Duke University School of Medicine, Durham, North Carolina.
Marco DispagnaDepartment of Radiation Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
Hamzah H AhmedDepartment of Pathology, Immunology and Laboratory Medicine, UF Health, UF Health Cancer Center, Southeast Center for Integrated Metabolomics, Clinical and Translational Science Institute, College of Medicine, University of Florida, Gainesville, Florida.ORCID 0000-0002-4806-8878
Mark L GonzalgoDepartment of Urology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida.
J Mark BrownDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Timothy J GarrettDepartment of Pathology, Immunology and Laboratory Medicine, UF Health, UF Health Cancer Center, Southeast Center for Integrated Metabolomics, Clinical and Translational Science Institute, College of Medicine, University of Florida, Gainesville, Florida.ORCID 0000-0003-1623-009X
Scott M WelfordDepartment of Radiation Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida. scott.welford@med.miami.edu.ORCID 0000-0002-9579-4223
Sylvester Comprehensive Cancer Center · USUniversity of Miami · USUniversity of Florida Health · USCleveland Clinic · USCleveland Clinic Lerner College of Medicine · USDuke University · USKing Abdulaziz University · SAUniversity of Tennessee Health Science Center · US
Funding
Tumor Biology Research ProgramP30CA240139 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Stephen D. Nimer · 2019 to 2026
$24.1MProject Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI Srinivasan Dasarathy · 2016 to 2026
$19.6MProject 3: Microbiota generated aryl sulfates and secondary bile acids in cardiometabolic diseaseP01HL147823 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI Stanley L Hazen · 2019 to 2026
$17.0MSoutheast Resource Center for Integrated Metabolomics (SECIM)U24DK097209 · NIDDK · UNIVERSITY OF FLORIDA · PI EDISON, ARTHUR S, YOST, RICHARD A. · 2013 to 2017
$9.2MAdipokine Signaling as a Therapeutically Targetable Driver of Tumor MetabolismR01CA254409 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WELFORD, SCOTT MICHAEL · 2021 to 2025
$1.8MThe Role of Bacterial Choline Metabolism in Host Stress ResponsesR01DK120679 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI BROWN, JONATHAN MARK · 2019 to 2022
$1.6MNCI NIH HHS P30 CA240139NCI NIH HHS R01 CA254409NHLBI NIH HHS P01 HL147823NIAAA NIH HHS P50 AA024333NIDDK NIH HHS R01 DK120679NIDDK NIH HHS U24 DK097209
Abstract
Clear cell renal cell carcinoma (ccRCC) is characterized by accumulation of neutral lipids and adipogenic transdifferentiation. We assessed adipokine expression in ccRCC and found that tumor tissues and patient plasma exhibit obesity-dependent elevations of the adipokine chemerin. Attenuation of chemerin by several approaches led to significant reduction in lipid deposition and impairment of tumor cell growth
Indexed as
Angiogenesis InhibitorsAnimalsCarcinoma, Renal CellCell Line, TumorFatty AcidsFemaleFerroptosisHumansKidney NeoplasmsLipid MetabolismMiceMice, NudeObesityAngiogenesis InhibitorsFatty Acids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.