ArticleJournal of the American Medical Directors Association2021
Increase in Frailty in Nursing Home Survivors of Coronavirus Disease 2019: Comparison With Noninfected Residents.
Article in Journal of the American Medical Directors Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06430073 (Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients: a Multicenter Observational Study (INFRAGEN)
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- The FRAIL-NH Scale: Systematic Review of the Use, Validity and Adaptations for Frailty Screening in Nursing Homes.The journal of nutrition, health & aging · 2021Pooled it
- Effect of infections, DNA methylation and telomere length on frailty trajectories in hospitalized older patients: the INFRAGEN study protocol.BMC geriatrics · 2025Observational
- Change in Feeding and Swallowing Function in Elderly Patients with Isolated Hospitalization for COVID-19: A Retrospective Cohort Study.Journal of general internal medicine · 2025Article
- Health, functioning and social engagement among older people living in long-term care facilities during the COVID-19 lockdown in Finland: a register-based cohort study.BMC public health · 2025Article
- Global burden and cross-country inequalities of nutritional deficiencies in adults aged 65 years and older, 1990-2021: population-based study using the GBD 2021.BMC geriatrics · 2025Article
- The association of non-severe COVID-19 infection and progression to frailty among robust older veterans.The journal of nutrition, health & aging · 2024Article
- COVID-19 infection and 2-year mortality in nursing home residents who survived the first wave of the pandemic.BMC geriatrics · 2024Article
- The Value of the COVID-19 Yorkshire Rehabilitation Scale in the Assessment of Post-COVID among Residents of Long-Term Care Facilities.Healthcare (Basel, Switzerland) · 2024Article
- The influence of nationwide COVID-19 lockdown on the functional impairment and long-term survival of dependent people for carrying out basic activities of daily living in a neighborhood of the city of Madrid, Spain: Orcasitas Cohort Longitudinal Study.Frontiers in public health · 2024Article
- Long COVID in long-term care: a rapid realist review.BMJ open · 2023Review
- Consequences of contact restrictions for long-term care residents during the first months of COVID-19 pandemic: a scoping review.European journal of ageing · 2023Article
- Identifying predictors of cognitive decline in long-term care: a scoping review.BMC geriatrics · 2023Article
- Frailty after COVID-19: The wave after?Aging medicine (Milton (N.S.W)) · 2023Review
- Long COVID and hypertension-related disorders: a report from the Japanese Society of Hypertension Project Team on COVID-19.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Review
- Cognitive Deficits in the Acute Phase of COVID-19: A Review and Meta-Analysis.Journal of clinical medicine · 2023Review
- Review
- Effects of SARS-CoV-2 infection on health and functional capacity in institutionalized older adults.Revista da Escola de Enfermagem da U S P · 2023Article
- National cross-sectional survey on psychological impact on French nursing homes of the first lockdown during the COVID-19 pandemic as observed by psychologists, psychomotor, and occupational therapists.Frontiers in public health · 2023Article
- Postural balance and its association with functionality and quality of life in non-hospitalized patients with post-acute COVID-19 syndrome.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2022Article
- Older Women Who Practiced Physical Exercises before the COVID-19 Pandemic Present Metabolic Alterations and Worsened Functional Physical Capacity after One Year of Social Isolation.Healthcare (Basel, Switzerland) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesInstitutionalized older adults have a high prevalence of frailty and disability, which may make them more vulnerable to the negative consequences of coronavirus disease 2019 (COVID-19). We investigated the impact of COVID-19 on the level of frailty, physical, and cognitive performance in nursing home residents.
designNested case-control study. SETTING AND
participantsThe study included nursing home residents who were infected with COVID-19 (case group, n = 76), matched by age to a control group (n = 76).
methodsParticipants' sociodemographic and medical data were collected, and they were also assessed for physical function (handgrip and walking speed), cognitive performance (Mini-Mental State Examination) and frailty (Frail-NH scale) before the first wave of the COVID-19 pandemic (October to December 2019, pre-COVID-19) and after (June to July 2020, post-COVID-19). COVID-19 symptoms and clinical course were recorded for the cases.
resultsBetween the pre- and post-COVID-19 assessments, we found a 19% greater deterioration in handgrip, a 22% greater decrease in walking speed, and a 21% greater increase in Frail-NH scores in cases compared with controls. In both cases and controls, on the other hand, there was a significant 10% decrease in Mini-Mental State Examination scores over the study period. Multivariable logistic regression showed that COVID-19 survivors had a 4-fold increased chance of developing frailty compared with controls (odds ratio 4.95, 95% confidence interval 1.13-21.6, P = .03), but not cognitive decline. CONCLUSIONS AND IMPLICATIONS: COVID-19 can accelerate the aging process of institutionalized older adults in terms of physical performance and frailty by around 20%. However, we found similar levels of decline in cognitive performance in both cases and controls, likely because of the burden of social isolation and containment measures on neuropsychological health.
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Registered trials
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