Evidence map›Paper›PMID 33757622›Full record

ReviewGene expression2021

Role of Noncoding RNAs in Acetaminophen-Induced Liver Injury.

Vivek Chowdhary, Pipasha Biswas, Kalpana Ghoshal

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gene expression, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Vivek ChowdharyDepartment of Pathology, College of Medicine, The Ohio State UniversityColumbus, OHUSA.
Pipasha BiswasComprehensive Cancer Center, College of Medicine, The Ohio State UniversityColumbus, OHUSA.
Kalpana GhoshalDepartment of Pathology, College of Medicine, The Ohio State UniversityColumbus, OHUSA.
The Ohio State University · US

Funding

Role of microR-122 in Hepatocarcinogenesis using Conditional Knockout MiceR01CA193244 · NCI · OHIO STATE UNIVERSITY · PI GHOSHAL, KALPANA · 2015 to 2019
$2.3M
Role of microRNA-122 in hepatocarcinogenesis using conditional knock out miceR01DK088076 · NIDDK · OHIO STATE UNIVERSITY · PI GHOSHAL, KALPANA · 2010 to 2013
$1.3M
NCI NIH HHS R01 CA193244NIDDK NIH HHS R01 DK088076
6 · The paper itself

Abstract

Genomic and transcriptomic analyses have well established that the major fraction of the mammalian genome is transcribed into different classes of RNAs ranging in size from a few nucleotides to hundreds of thousands of nucleotides, which do not encode any protein. Some of these noncoding RNAs (ncRNAs) are directly or indirectly linked to the regulation of expression or functions of 25,000 proteins coded by <2% of the human genome. Among these regulatory RNAs, microRNAs are small (2125 nucleotides) RNAs that are processed from precursor RNAs that have stemloop structure, whereas noncoding RNAs >200 nucleotides are termed long noncoding RNAs (lncRNAs). Circular RNAs (circRNAs) are newly identified lncRNA members that are generated by back-splicing of primary transcripts. The functions of ncRNAs in modulating liver toxicity of xenobiotics are emerging only recently. Acetaminophen (

Indexed as

AcetaminophenAnalgesics, Non-NarcoticAnimalsChemical and Drug Induced Liver InjuryCytochrome P450 Family 3HumansRNA, UntranslatedAcetaminophenAnalgesics, Non-NarcoticCytochrome P450 Family 3RNA, Untranslated

Identifiers

PMID33757622
PMCPMC8201654
OpenAlexW3136367165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.