Evidence map›Paper›PMID 33757457›Full record

ArticleBMC neurology2021

Concomitant Guillain-Barre syndrome with COVID-19: a case report.

Nuvia Mackenzie, Eva Lopez-Coronel, Alberto Dau, Dieb Maloof, Salvador Mattar, Jesus Tapia Garcia, Briyis Fontecha, Cristina M Lanata, Hernan Felipe Guillen-Burgos

Open access · goldAbstract readCase Reports
In one paragraph

Article in BMC neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Guillain Barre Syndrome as a Complication of COVID-19: A Systematic Review.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2022
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  8. Acute neuromuscular syndromes with respiratory failure during COVID-19 pandemic: Where we stand and challenges ahead.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2022
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  15. A Review of Neurological Involvement in Patients with SARS-CoV-2 Infection.Medical science monitor : international medical journal of experimental and clinical research · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Nuvia MackenzieCenter for Clinical and Translational Research, La Misericordia Clínica Internacional, Barranquilla, Colombia.
Eva Lopez-CoronelCenter for Clinical and Translational Research, La Misericordia Clínica Internacional, Barranquilla, Colombia.
Alberto DauCenter for Clinical and Translational Research, La Misericordia Clínica Internacional, Barranquilla, Colombia.
Dieb MaloofCenter for Clinical and Translational Research, La Misericordia Clínica Internacional, Barranquilla, Colombia.
Salvador MattarCenter for Clinical and Translational Research, La Misericordia Clínica Internacional, Barranquilla, Colombia.
Jesus Tapia GarciaCenter for Clinical and Translational Research, La Misericordia Clínica Internacional, Barranquilla, Colombia.
Briyis FontechaCenter for Clinical and Translational Research, La Misericordia Clínica Internacional, Barranquilla, Colombia.
Cristina M LanataRosalind Russell/Ephraim P Engleman Rheumatology Research Center, University of California, San Francisco, California, USA.
Hernan Felipe Guillen-BurgosCenter for Clinical and Translational Research, La Misericordia Clínica Internacional, Barranquilla, Colombia. hernan.guillen@unisimonbolivar.edu.co.ORCID http://orcid.org/0000-0003-1835-431X
Universidad Internacional · MXUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring the Coronavirus disease 2019 (COVID-19) pandemic, different neurological manifestations have been observed. However, only a few cases of Guillain-Barre syndrome (GBS) and COVID-19 have been reported. Therefore, the aim of this study is to investigate a case of concomitant GBS with COVID-19 in Colombia. CASE PRESENTATION: A 39-year-old woman was admitted to a teaching hospital in Barranquilla, Colombia with a history of progressive general weakness with lower limb dominance. Previous symptoms such as ageusia, anosmia and intense headache were reported. Upon admission, facial diplegia, quadriparesis with lower extremity predominance and Medical Research Council muscular strength of 2/5 in the lower limbs and 4/5 in the upper limbs were reported. During clinical evolution, due to general areflexia, hypertensive emergency and progressive diaphragmatic weakness, the patient was admitted to an intensive care unit. The cerebrospinal fluid analysis showed protein-cytological dissociation and the GBS diagnosis was confirmed via a nerve conduction and electromyography test. With regard to the symptoms before hospitalisation, SARS-CoV-2 diagnostic testing was performed with positive results in the second test. The patient was managed with supportive care and was discharged after 20 days of hospitalization with clinical improvement.

conclusionsOnly a few cases of COVID-19 with GBS have been reported. Different subtypes have been previously identified, such as Miller-Fisher syndrome and dysautonomic GBS with SARS-CoV-2 infection. This study investigated the first confirmed case of COVID-19 with concomitant GBS in Colombia. In patients with GBS, several viral and bacterial pathogens have been found in case-control studies but the factors that induce the immune-mediated destruction of the nerve tissues have not been determined. Further studies are needed to determine the possible association between COVID-19 exposure and GBS.

Indexed as

AdultBell PalsyColombiaCOVID-19ElectromyographyFemaleGuillain-Barre SyndromeHospitalizationHumansNeural ConductionQuadriplegiaCase reportCOVID-19Guillain-Barre syndromeSARS-CoV-2

Identifiers

PMID33757457
PMCPMC7985584
OpenAlexW3136853223

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.