Evidence map›Paper›PMID 33757381›Full record

ArticleActa orthopaedica2021

Pain, osteolysis, and periosteal reaction are associated with the STRYDE limb lengthening nail: a nationwide cross-sectional study.

Jan Duedal Rölfing, Søren Kold, Tobias Nygaard, Mindaugas Mikuzis, Michael Brix, Christian Faergemann, Martin Gottliebsen, Michael Davidsen, Juozas Petruskevicius, Ulrik Kähler Olesen

Open access · goldAbstract read
In one paragraph

Article in Acta orthopaedica, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  6. Review
  7. Article
  8. Analysis of retrieved STRYDE nails.Bone & joint open · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Jan Duedal RölfingOrthopaedic Reconstruction and Children's Orthopaedics, Aarhus University Hospital, Aarhus.
Søren KoldDepartment of Orthopaedics, Interdisciplinary Orthopaedics, Aalborg University Hospital, Aalborg.
Tobias NygaardDepartment of Orthopaedics, Limb Lengthening and Bone Reconstruction Unit, Rigshospitalet, Copenhagen.
Mindaugas MikuzisDepartment of Orthopaedics, Interdisciplinary Orthopaedics, Aalborg University Hospital, Aalborg.
Michael BrixDepartment of Orthopaedics, Odense University Hospital, Odense, Denmark.
Christian FaergemannDepartment of Orthopaedics, Odense University Hospital, Odense, Denmark.
Martin GottliebsenOrthopaedic Reconstruction and Children's Orthopaedics, Aarhus University Hospital, Aarhus.
Michael DavidsenOrthopaedic Reconstruction and Children's Orthopaedics, Aarhus University Hospital, Aarhus.
Juozas PetruskeviciusOrthopaedic Reconstruction and Children's Orthopaedics, Aarhus University Hospital, Aarhus.
Ulrik Kähler OlesenDepartment of Orthopaedics, Interdisciplinary Orthopaedics, Aalborg University Hospital, Aalborg.
Aalborg University Hospital · DKAarhus University Hospital · DKOdense University Hospital · DKAarhus University · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose - Observing serious adverse events during treatment with the Precice Stryde bone lengthening nail (NuVasive, San Diego, CA, USA), we conducted a nationwide cross-sectional study to report the prevalence of adverse events from all 30 bone segments in 27 patients treated in Denmark.Patients and methods - Radiographs of all bone segments were evaluated regarding radiographic changes in February 2021. We determined the number of bone segments with late onset of pain and/or radiographically confirmed osteolysis, periosteal reaction, or cortical hypertrophy in the junctional area of the nail.Results - In 30 bone segments of 27 patients we observed radiographic changes in 21/30 segments of 20/27 patients, i.e., 19/30 osteolysis, 12/30 periosteal reaction (most often multi-layered), and 12/30 cortical hypertrophy in the area of the junction between the telescoping nail parts. Late onset of pain was a prominent feature in 8 patients. This is likely to be a prodrome to the bony changes. Discoloration (potential corrosion) at the nail interface was observed in multiple removed nails. 15/30 nails were still at risk of developing complications, i.e., were not yet removed.Interpretation - All Stryde nails should be monitored at regular intervals until removal. Onset of pain at late stages of limb lengthening, i.e., consolidation of the regenerate, should warrant immediate radiographic examination regarding osteolysis, periosteal reaction, and cortical hypertrophy, which may be associated with discoloration (potential corrosion) of the nail. We recommend removal of Stryde implants as early as possible after consolidation of the regenerate.

Indexed as

Bone NailsAdolescentAdultAgedBone LengtheningChildCross-Sectional StudiesDenmarkFemurHumansMiddle AgedOsteolysisPeriosteumPostoperative ComplicationsPostoperative PainRadiography

Identifiers

PMID33757381
PMCPMC8428270
OpenAlexW3137039674

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.