The antioxidant MnTBAP does not effectively downregulate CD4 expression in T cells in vivo.

Navid Manouchehri, Dikran R Guisso, Rehana Z Hussain, Berge A Minassian, Olaf Stüve

Abstract read

In one paragraph

Article in Journal of neuroimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Navid ManouchehriDepartment of Neurology & Neurotherapeutics, University of Texas Southwestern Medical School, Dallas, TX, USA.

Dikran R GuissoDepartment of Pediatrics, University of Texas Southwestern Medical School, Dallas, TX, USA.

Rehana Z HussainDepartment of Neurology & Neurotherapeutics, University of Texas Southwestern Medical School, Dallas, TX, USA.

Berge A MinassianDepartment of Neurology & Neurotherapeutics, University of Texas Southwestern Medical School, Dallas, TX, USA; Department of Pediatrics, University of Texas Southwestern Medical School, Dallas, TX, USA. Electronic address: berge.minassian@utsouthwestern.edu.

Olaf StüveDepartment of Neurology & Neurotherapeutics, University of Texas Southwestern Medical School, Dallas, TX, USA; Neurology Section, VA North Texas Health Care System, Dallas, TX, USA. Electronic address: olaf.stuve@utsouthwestern.edu.

Funding

Suppressing glycogen storage with small molecule inhibitors as a therapeutic approach to Lafora DiseaseP01NS097197 · NINDS · UNIVERSITY OF KENTUCKY · PI GAO, TIANYAN · 2016 to 2021

$9.0M

NINDS NIH HHS P01 NS097197

6 · The paper itself

Abstract

The antioxidant MnTBAP was previously shown to down-regulate the surface expression of CD4 molecule in T cells. This observation obviously holds great potential impact in a number of pathological human conditions, including autoimmunity. Three different single doses of MnTBAP reduced the frequency of CD4

Indexed as

AnimalsAntioxidantsCD4 AntigensCD4-Positive T-LymphocytesDown-RegulationEncephalomyelitis, Autoimmune, ExperimentalMetalloporphyrinsMiceMice, Inbred C57BLAntioxidantsCD4 Antigensmanganese(III)-tetrakis(4-benzoic acid)porphyrinMetalloporphyrinsAnimal models therapyCD4 MnTBAPExperimental autoimmune encephalomyelitisMultiple sclerosis

Identifiers

PMID33756414

DOI10.1016/j.jneuroim.2021.577544

PMCPMC8109275

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.