Evidence map›Paper›PMID 33756281›Full record

Observational studySleep medicine2021

Objectively assessed sleep-disordered breathing during pregnancy and infant birthweight.

Marquis Hawkins, Corette B Parker, Susan Redline, Jacob C Larkin, Phyllis P Zee, William A Grobman, Robert M Silver, Judette M Louis, Grace W Pien, Robert C Basner and 9 more

Registry-linked trialOpen access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Sleep medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02231398 (Pregnancy as a Window to Future Cardiovascular Health), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02231398 completednot on this map

Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes as Predictors of Increased Risk Factors for Cardiovascular Disease

TypeobservationalSponsorRTI InternationalRan2014 to 2020Enrolled4,509ConditionsPregnancy Complicated by Cardiovascular Disorders as Postpartum Condition, Delivered During Previous Episode, Breathing-Related Sleep Disorder
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Heliyon · 2024
    Article
  5. Review
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 1 country.

Marquis HawkinsUniversity of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA. Electronic address: mah400@pitt.edu.
Corette B ParkerRTI International, Research Triangle Park, NC, USA.
Susan RedlineHarvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.
Jacob C LarkinDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Phyllis P ZeeDepartment of Neurology, Northwestern University, Chicago, IL, USA.
William A GrobmanDepartment of Obstetrics, Gynecology-Maternal Fetal Medicine & Preventive Medicine, Northwestern University, Chicago, IL, USA.
Robert M SilverDepartment of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA.
Judette M LouisUniversity of South Florida Morsani College of Medicine, Tampa, FL, USA.
Grace W PienDepartment of Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Robert C BasnerDepartment of Obstetrics and Gynecology, Columbia University, New York, NY, USA.
Judith H ChungDepartment of Obstetrics and Gynecology, University of California, Irvine, CA, USA.
David M HaasDepartment of Obstetrics and Gynecology, School of Medicine, Indiana University, Indianapolis, IN11, USA.
Chia-Ling Nhan-ChangDepartment of Obstetrics and Gynecology, Columbia University, New York, NY, USA.
Hyagriv N SimhanDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nathan R BlueDepartment of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA.
Samuel ParryDepartment of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, PA, USA.
Uma ReddyDepartment of Obstetrics, Gynecology & Reproductive Services, Yale University, New Haven, CT, USA.
Francesca FaccoDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
NICHD NuMoM2b and NHLBI NuMoM2b Heart Health Study Networks
University of Pittsburgh · USColumbia University · USNorthwestern University · USUniversity of Utah · USBrigham and Women's Hospital · USIndiana University – Purdue University Indianapolis · USJohns Hopkins University · USRTI International · USUniversity of California, Irvine · USUniversity of Pennsylvania · USUniversity of South Florida · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Pregnancy as a Window to Future Cardiovascular Health: Adverse Pregnancy Outcomes Supplement RequestU10HL119991 · NHLBI · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2013 to 2018
$12.6M
NICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD087230 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HYAGRIV N SIMHAN · 2016 to 2026
$3.2M
Utah Women's Reproductive Health Research Career Development ProgramK12HD085816 · NICHD · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2015 to 2024
$3.2M
Sleep Disturbance and risk for adverse pregnancy outcomesR01HL105549 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GROBMAN, WILLIAM ADAM, ZEE, PHYLLIS C. · 2011 to 2013
$2.0M
Pregnancy as a Window for Future Cardiovascular HealthU10HL119992 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GROBMAN, WILLIAM ADAM · 2013 to 2016
$536k
Pregnancy as a Window to Future Cardiovascular HealthU10HL120034 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAPNER, RONALD · 2013 to 2016
$483k
Pregnancy as a Window to Future Cardiovascular HealthU10HL120018 · NHLBI · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2013 to 2016
$395k
Pregnancy as a Window to Future Cardiovascular HealthU10HL120006 · NHLBI · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SIMHAN, HYAGRIV N · 2013 to 2016
$218k
Pregnancy as a Window to Future Cardiovascular HealthU10HL119990 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI HAAS, DAVID M. · 2013 to 2016
$202k
Pregnancy as a Window to Future Cardiovascular HealthU10HL120019 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI WING, DEBORAH A · 2013 to 2016
$199k
Pregnancy as a Window to Future Cardiovascular HealthU10HL119993 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PARRY, SAMUEL I. · 2013 to 2016
$194k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL105549NHLBI NIH HHS U10 HL119989NHLBI NIH HHS U10 HL119990NHLBI NIH HHS U10 HL119991NHLBI NIH HHS U10 HL119992NHLBI NIH HHS U10 HL119993NHLBI NIH HHS U10 HL120006NHLBI NIH HHS U10 HL120018NHLBI NIH HHS U10 HL120019NHLBI NIH HHS U10 HL120034NICHD NIH HHS K12 HD085816NICHD NIH HHS UG1 HD087230
6 · The paper itself

Abstract

backgroundSleep-disordered breathing (SDB) in pregnancy is associated with adverse maternal outcomes. The relationship between SDB and infant birthweight is unclear. This study's primary aim is to determine if objectively measured SDB in pregnancy is associated with infant birthweight.

methodsWe measured SDB objectively in early (6-15 weeks' gestation) and mid (22-31 weeks' gestation) pregnancy in a large cohort of nulliparous women. SDB was defined as an Apnea-Hypopnea Index ≥5 and in secondary analyses we also examined measures of nocturnal hypoxemia. We used a modified Poisson regression approach to estimate relative risks (RR) of large-for-gestational-age (LGA: >90th percentile for gestational age) and small-for-gestational-age (SGA: <10th percentile for gestational age) birthweights.

resultsThe prevalence of early-pregnancy SDB was nearly 4%. The incidence of mid-pregnancy SDB was nearly 6.0%. The prevalence of LGA and SGA was 7.4% and 11.9%, respectively. Early-pregnancy SDB was associated with a higher risk of LGA in unadjusted models (RR 2.2, 95% CI 1.3-3.5) but not BMI-adjusted models (aRR 1.0, 95% CI 0.6-1.8). Mid-pregnancy SDB was not associated with SGA or LGA. Mid-pregnancy nocturnal hypoxemia (% of sleep time <90% oxygen saturation) and increasing nocturnal hypoxemia from early to mid-pregnancy were associated with a higher risk of LGA in BMI-adjusted models. SDB and nocturnal hypoxemia were not associated with SGA.

conclusionsSDB in pregnancy was not associated with an increased risk of LGA or SGA birthweight, independent of BMI. Some measures nocturnal hypoxemia were associated with an increase in LGA risk, independent of BMI. ClinicalTrials.gov Registration number NCT02231398.

Indexed as

Infant, Small for Gestational AgeSleep Apnea SyndromesBirth WeightCohort StudiesFemaleGestational AgeHumansInfantInfant, NewbornPregnancyAbnormal fetal growthNocturnal hypoxemiaSleep apneaSleep-disordered breathing

Identifiers

PMID33756281
PMCPMC8341176
OpenAlexW3135668443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.